Can Mirna upregulate gene expression?
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| In addition, miRNA are able to indirectly influence gene expression potential at the transcriptional level via modulation of the function of components of the epigenetic machinery (DNA methylation and histone modifications). | |
66 Citations | Taken together, these data for the first time show that miRNA* can positively modulate gene expression. |
| Moreover, the transferred miRNA is functional and could regulate gene expression in neighboring cells. | |
| This could be achieved by enhancing mRNA degradation through an additive effect from multiple miRNA targeting. Genome-scale analysis on the nature of miRNA target genes has revealed a general mechanism for miRNA regulation of human gene expression. | |
77 Citations | A single miRNA can potentially regulate the expression of multiple genes and the proteins encoded. |
14 Citations | Our studies systematically investigated hundreds of miRNA target genes, shed light on factors influencing miRNA functions, and suggested a new mechanism by which differential target repression by miRNAs regulates endogenous gene expression. |
| Those miRNA might therefore have significant further effect on gene expression by repressing the expression of genes involved in transcriptional regulation. | |
51 Citations | Unlinking their expression has the potential to change the expression of multiple miRNA targets and shift a biological response. |
19 Citations | These results support the possible role of miRNA interaction in the expression of its target genes and also ability of environmental toxicant to deregulate miRNA expression. |
45 Citations | Taken together, our results elucidate the effect of different sequence features on miRNA-mediated regulation and demonstrate the predictability of their effect on gene expression with applications in regulatory genomics and synthetic biology. MiRNAs are known regulators of gene expression. |
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