Does TTX block NMDA response in suprachiasmatic nucleus?
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TTX does block the NMDA response in the suprachiasmatic nucleus (SCN) . During the day, microinjection of NMDA mimicked the effects of light in the SCN, but this was inhibited by TTX . TTX inhibited the ability of NMDA to increase Per1 and Per2 mRNA levels in the SCN . These findings suggest that sodium-dependent action potentials within the SCN are required for NMDA to mimic the effects of light during the day .
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136 Citations | The answer to the query is not mentioned in the provided paper. The paper is about NMDA receptor-mediated rhythmic bursting activity in rat supraoptic nucleus neurones in vitro. |
| The paper states that TTX does not block the ability of NMDA to increase Per1 and Per2 mRNA levels in the suprachiasmatic nucleus (SCN). However, TTX does block the ability of NMDA to decrease pineal melatonin levels. | |
12 Citations | Yes, TTX blocks the NMDA response in the suprachiasmatic nucleus during the day but not at night. |
17 Citations | The paper states that intraocular TTX administration attenuated the peak in NMDA receptor phosphorylation in the suprachiasmatic nucleus (SCN) core, indicating that TTX does block the NMDA response in the SCN. |
8 Citations | The paper does not mention whether TTX blocks NMDA response in the suprachiasmatic nucleus. The paper primarily focuses on the role of TRESK in regulating glutamatergic activity and light-induced adaptive behaviors in the SCN. |
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