Showing papers on "Derivative (chemistry) published in 1977"

Synthesis and identification of the major metabolites of prazosin formed in dog and rat

Abstract: The 6-O-demethyl and 7-O-demethyl analogues of the new antihypertensive drug prazosin [2-[4-(2-furoyl)-piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline hydrochloride] have been unequivocally synthesized via separate ten-step reaction sequences starting from isovanillin and vanillin, respectively. The 6-O-demethyl derivative was found to be identical with the major prazosin metabolite formed in dog and rat, while the 7-O-demethyl derivative was identical with another, less prevalent but significant metabolite. Two minor metabolites of prazosin, 2-(1-piperazinyl)-4-amino-6,7-dimethoxyquinazoline and 2,4-diamino-6,7-dimethoxyquinazoline, are also described. All four metabolites are less potent blood pressure lowering agents in dogs than prazosin but may contribute to its antihypertensive effect, since they account for a major portion of the administered dose.

Rapidly curable, storage-stable organosilicon compositions

Abstract: An organosilicon composition is disclosed which is storage-stable in the absence of moisture and is rapidly curable into elastomers with self-adherent properties in the presence of water at room temperature. Such compositions are prepared by mixing: (a) at least one α,ω-di(hydroxy) diorganopolysiloxane polymer, (b) at least one organosilicon resin, (c) at least one alkoxylated organosilicon compound, and (d) at least one organic titanium derivative.

Color photographic processing method

Abstract: A method for processing a silver halide color photographic light-sensitive material which comprises developing an image-wise exposed silver halide color light-sensitive material in the presence of (a) an aromatic primary amine color developing agent, (b) hydroxylamine or a hydroxylamine derivative, and (c) a 1-aryl-3-pyrazolidone derivative containing two substituent groups at the 4-position thereof.

Synthesis and kinetic properties of a new NAD+ derivative carrying a vinyl group.

Abstract: A new NAD+ derivative carrying a vinyl group, NAD+-N6-[N-(N-acryloyl-l-methoxycarbonyl-5-aminopentyl)-propioamide (M-NAD+) was synthesized as is summarized in Fig. 1. The NAD+ derivative was converted to a water soluble macromolecular NAD+ derivative (P-NAD+) by copolymerization with acrylamide.

Production of polyurethane foam of reduced tendency to form embers when burned

Abstract: Flexible polyurethane foam having reduced tendency to form burning embers when it is ignited and burned is provided by incorporating into the reaction mixture before foaming a derivative of melamine wherein one or more hydrogens have been replaced by hydroxymethyl and/or lower alkoxymethyl groups. In one embodiment, flexible polyurethane foams of increased flame retardance are also provided, by also incorporating a halogenated phosphorus ester into the reaction mixture before foaming.

The structure of clavicipitic acid, an azepinoindole derivative from Claviceps fusiformis

Abstract: Clavicipitic acid, an amphoteric indole derivative from Claviceps fusiformis, is identified by mass spectral and 1H n.m.r. studies as 3,4,5,6-tetrahydro-6-(2-methylprop-1-enyl)-1H-azepino[5.4,3-cd]indole-4-carboxylic acid (4) and shown to exist in two diastereoisomeric forms.

Brake grease compositions

Abstract: Grease compositions comprising (A) a specific polyoxypropylene glycol monoether as the lubricating base oil and (B) a specific gelling agent as the thickening agent, consisting of at least one diurea compound represented by the formula ##STR1## wherein R 1 is a divalent aromatic hydrocarbon radical, and R 2 and R 3 a cyclohexyl group, a cyclohexyl derivative group having 7-12 carbon atoms, or an alkyl group having 8-20 carbon atoms.

Mass spectrometric and nuclear magnetic resonance confirmation of a 3,3‐spirocyclic indole derivative formed from melatonin and related acyl tryptamines

Abstract: When melatonin is reacted with pentafluoropropionic anhydride for selected ion monitoring or electron capture gas chromatographic analysis a volatile product results. Examination of the product by combined gas chromatography mass spectrometry has established that the molecular weight of 360 corresponds to the addition of one molecule of pentafluoropropionic acid followed by dehydration. Further spectroscopic and chemical examination using mass spectrometry and nuclear magnetic resonance with isotopic labelling has established that the product is a 3,3-spirocyclic indole derivative. Several analogous compounds were also examined and their mass spectra studied.

Photoinitiators for photopolymerizable coating compositions

Abstract: Photopolymerizable coating compositions contain, as the binder, olefinically unsaturated compounds having a boiling point above 50° C, together with from 0.5 to 15% by weight of photoinitiators, based on the binder. The photoinitiators are a mixture of an aromatic carbonyl compound A, which is a derivative of benzoin or benzil, which has at least one carbon-oxygen single bond in the α-position relative to the carbonyl group, an aromatic carbonyl compound B which is derived from benzophenone, fluorenone, anthraquinone, xanthene, thioxanthone or acridone, and an amine C of the general formula ##STR1## where R', R" and R"' are H, alkyl of 1 to 10 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, aryl, hydroxyalkyl of 1 to 8 carbon atoms or alkoxyalkyl of 2 to 4 carbon atoms, but at most 2 substituents are H and at most 2 substituents are aromatic. These coating compositions may be used for finishing various substrates, as fillers or as printing inks.

Method of producing magnetic material with alkaline borohydrides

Abstract: A method of producing a magnetic material comprising reducing in a solution of a salt of a metal capable of forming a ferromagnetic material with a reducing agent comprising at least one of a borohydride and a derivative thereof, in a solution containing a hydroxide ion concentration of at least about 0.001N and not higher than about 0.6N.

Making a nitrodiarylamine by reacting an alkali metal salt of a formamide with a nitrohaloarene

Abstract: Preparation of a nitrodiarylamine from a nitrohaloarene and alkali metal salt of the formyl derivative of a primary aromatic amine is disclosed.

The amidomethylation and bromination of Fischer's base.The preparation of some new polymethine dyes

Abstract: The amidomethylation of Fischer's base (1,3,3-trimethyl-2- methyleneindoline) with N-hydroxy-methylphthalimide gives, as the main product, the 5-phthalimidomethyl derivative (4). This compound has been converted into its parent amine (5) from which a N-chloroacetyl derivative (6) was readily obtained. Fischer's base reacted with one equivalent of dibromoisocyanuric acid to give the 5-bromo derivative (7) and with two equivalents to give the 5,6-dibromo derivative (8). All five substituted Fischer's bases have been used to prepare representative polymethine dyes, the ultraviolet spectral and lightfastness (on wool) properties of which are described. Dyes containing one bromine atom impart particularly brilliant shades to wool. A dye containing the N-chloro-acetamidomethyl substituent proved to be fibre-reactive.

Immunological adjuvant constituted by the p-amino-phenyl derivative of N-acetyl-muramyl-L-alanyl-D-isoglutamine

Abstract: The adjuvant is 2-(p-amino-phenyl-2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-alanyl-D-isoglutamine, which compound in its β glucoside form, corresponds with the formula ##STR1## It is notably useful for favoring immunitory responses relative to antigens of low immunogenicity.

EPR dispersant VI improver

Abstract: Lubricating oil additives having both dispersant and viscosity-index improving properties are prepared by reacting an ethylene-propylene copolymer with chlorine and/or an alpha-beta unsaturated dicarboxylic acid or derivative, and then reacting the resulting intermediate with certain amines.