Showing papers on "Liquid paraffin published in 1989"

Preparation of microspheres of water-soluble pharmaceuticals

Abstract: An emulsion-solvent evaporation procedure involving the dispersion of an alcoholic solution of an active in liquid paraffin was used to prepare microspheres of water-soluble pharmaceuticals using ethylcellulose as a carrier. The effects of surfactant, plasticizer, drug loading, and agitation speed on drug release rate from the microspheres were evaluated. The release rates of water-soluble drugs from microspheres, ranging from 100 and 500 microns in diameter, were sustained over an extended time and were found to be related to the ratio of drug to polymer in the final product.

Creamy hair dye composition

Abstract: PURPOSE:To obtain the title composition with hardly any effects on human bodies and irritant smell even if ammonia is contained for providing hair dyeing treatment effects, by adding an oily ingredient and surfactant to an alkaline agent containing ammonia and ammonium salt, water and oxidation dye intermediate. CONSTITUTION:A creamy hair dye composition containing an alkaline agent containing ammonia and an ammonium salt (especially preferably ammonium salts of hydrochloric acid, nitric acid, sulfuric acid, bisulfuric acid, phosphoric acid, acetic acid, oxalic acid and citric acid), water, an oxidation dye intermediate, an oily ingredient (especially preferably paraffin, liquid paraffin, bees wax, squalane, vaseline, lanolin, silicone derivative, higher fatty acid and higher alcohol) and a surfactant (e.g., alkyltrimethylammonium salt). The above- mentioned composition especially preferably contains 1-10wt.% aqueous ammonia in 28% concentration and 0.1-10wt.% ammonium salt and is adjusted to pH8-12.

Therapy and clinical progress of cattle with dilatation and torsion of the caecum.

Abstract: One hundred and eleven heifers and cows with caecal dilatation and torsion were examined and their subsequent progress monitored. Using various criteria it was decided whether the animal was to be slaughtered or treated conservatively or surgically. Conservative treatment consisted of a continuous drip infusion containing neostigmine and of purgatives such as liquid paraffin, sometimes in combination with sodium sulphate. Surgical treatment consisted of laparotomy on the right flank with emptying and sometimes partial resection of the caecum. Five animals had to be slaughtered before or during surgery and another five which developed severe peritonitis were slaughtered after surgery. Fifty-nine animals underwent surgery once without resection of the caecum and 20 with. Another 14 animals needed surgery twice.

Some basic studies on the influence of surface contamination on adhesion force between wheel and rail at higher speeds

Abstract: In order to investigate basically the influence of wheel/rail surface contamination on the adhesion force at higher speeds, traction force and slip ratio were measured with two types of rolling contact testing machines by taking a small amount of liquid paraffin as a contaminating model. And some theoretical analyses were done on the traction-slip relationship as well as the maximum traction coefficient, that is, the adhesion coefficient by taking account of the static and kinetic friction coefficients as well as contact rigidity.

Sublimation type thermal transfer material

Abstract: PURPOSE: To stabilize running properties without generating delamination or the lowering of sensitivity by providing a gradient to the content of the substance having lubricity or releasability in a dye transfer contributing layer in the longitudinal direction thereof so that the content of the substance having lubricity or releasability in the dye transfer contributing layer becomes much in the free surface part thereof. CONSTITUTION: A gradient is provided in the content of the substance having lubricity or releasability in a dye transfer contributing layer in the longitudinal direction thereof so that the content of the substance having lubricity or releasability in the dye transfer contributing layer becomes much in the free surface part thereof as compared with the part adjacent to a dye supply layer. The thickness of the transfer contributing layer is pref. 0.1 - 2μm and the thickness of the dye supply layer is pref. 0.5 - 8μm. As an embodiment of the substance having lubricity or releasability, there are a petroleum type lubricant such as liquid paraffin, a silicone type lubricating substance, a salt of higher fatty acid or the like. The content of said substance in the dye transfer contributing layer is pref. 0 - 10wt.% in the part adjacent to the dye supply layer and 1 - 30wt.% in the free surface part. The gradient of the content of the lubricant in the dye transfer contributing layer in the longitudinal direction thereof may be linear or stepwise. COPYRIGHT: (C)1991,JPO&Japio

Successive sequential extractive disintegration of coal in coal-derived solvents under ambient pressure

Abstract: Assam coal was successively extracted in anthracene oil, quinoline, and liquid paraffin. About 68% of the coal was rendered extractable through successive extraction in anthracene oil followed by quinoline and then finally in liquid paraffin. The combined total extractability of coal in all the solvent systems increased with an increase in the extraction time in successive extractions. Assam, Talcher, and Raniganj coals and Neyveli lignite gave more than 50% extraction yields through the successive extractive disintegration using an anthracene oil-quinoline-liquid paraffin solvent system. Possible explanations for successive extractive disintegration of coal in anthracene oil-quinoline-liquid paraffin solvents are given

Cold tolerance mechanisms of the free-living stages of Trichostrongylus colubriformis (Nematoda).

Abstract: 1. All free-living stages of the nematode parasite of sheep, Trichostrongylus colubriformis Giles, survived exposure to freezing temperatures in contact with water, with the exception of the first-stage juvenile (J1). The third-stage juvenile (J3) was the most resistant stage. The order of relative survival of the different stages was different from that of the lowest F50 (the temperature at which 50% froze), suggesting that an ability to supercool was not the only determinant of survival. 2. The F50 was shown to be a good measure of the degree of supercooling and to extend greatly the lower size limit of organisms that could be measured. 3. The J3 uses a freeze-avoiding strategy by supercooling when in air or covered by liquid paraffin. In water it uses a mixture of freeze-avoiding and freeze-tolerant strategies, with a proportion of the population surviving freezing caused by exogenous ice nucleation. 4. Removal of the J3 sheath results in a shift from freeze avoidance to freeze tolerance, with an overall reduction in survival. A major function of the sheath may be to reduce the probability of exogenous ice nucleation.

Changes of mesophase structure of BRIJ 96/water mixtures on addition of liquid paraffin

Abstract: The influence of the addition of liquid paraffin (LP) on the structure of the lamellar (Lα) and hexagonal (H1) mesophases formed in mixtures of water (W) and BRIJ 96 (B) was studied. Mesophases were identified using polarization microscopy and small angle x-ray diffraction (SAXD). Repeat spacings were also determined with SAXD. Depending on theW/B ratio, addtion ofLP toLα gives a large, almost linear one-dimensional swelling or an initial swelling followed by a gradual transition to H1.Lα with a highLP-content gives a diffraction pattern showing only the first order diffraction maximum, possibly a result of undulations of the layers. The lamellar structure, however, was confirmed using freeze fracture electron microscopy (FFEM). Addition ofLP to H1 gives an initial swelling followed by a transition to a transparent, highly viscous, isotropic phase, called the gel-phase (G). The diffraction pattern obtained fromG yields little information on its structure. A large swelling ofG withLP was observed. From the degree of swelling as a function of hydrocarbon content it was inferred that this phase consists of spherical aggregates forming a close-packed structure. Using FFEM, textures were visualized resembling those obtained from the isotropic mesophase (I1) in water-surfactant mixtures. Finally, geometrical factors are discussed that may play a role in the formation of the gel-phase.

Non-emulsion-type foaming aerosol composition

Abstract: PURPOSE: To obtain a foam aerosol composition excellent in both detergency and properties in use and having good stability by mixing a liquid oil component, a solid oil component, and a propellant. CONSTITUTION: A non-emulsified foam aerosol composition comprising a liquid oil component (A), a solid oil component (B), and a propellant. Examples of the component (A) include those that are liquid at ordinary temperature, such as a liquid oil or fat (e.g. soybean oil), a hydrocarbon (e.g. liquid paraffin), a higher alcohol fatty acid (e.g. oleic acid), a higher alcohol (e.g. lauryl alcohol), a silicone (e.g. methylpolysiloxane), and an ester (e.g. isopropyl palmitate). The amount of the component (A) to be incorporated is preferably 30-89.99wt.% based on total stock solution. Examples of the component (B) include those that are solid at ordinary temperature, such as a wax (e.g. carnauba wax), a hydrocarbon, a fatty acid, and an aliphatic alcohol. The component (B) accounts for at least 0.1wt.% of total stock solution. As the propellant, those usually used for aerosol products can be employed, preferably in an amount of 3-90wt.%. COPYRIGHT: (C)1991,JPO&Japio

Multi-edged rodent bait

Abstract: A multi-edged rodent bait unit is disclosed having a quantity of rodent meal and rodenticide formed into an extended article having planar front and rear faces. The article has a substantially constant cross section along its length and has four sides perpendicular to the front and rear faces. At least one side has portions defining a V-shaped groove. The walls of the groove meet the faces of the side at angle of less than 150 degrees to form linear edges which are easily gnawed by a rodent. A preferred form of the bait unit has a single groove on each side of the bait unit. A second preferred form has two grooves on each side, and a third preferred form has alternating grooves and ribs. The bait unit of this invention is formed by mixing a rodenticide with rotent meal at room temperature and adding liquid paraffin at approximately 145 degrees Fahrenheit to the mixture and blending the paraffin into the mixture to form a die homogeneous mass. The mass is then extruded through a die at high pressures wherein the die has portions to form V-shaped grooves in the sides of the extruded mass. The extruded mass is then cut to desired lengths. The bait unit according to this invention has an increased number of gnawing edges for a rodent to feed upon and is advantageously able to withstand weathering.

Biopharmaceutical evaluation of sustained-release ethylcellulose microcapsules containing amoxicillin using beagle dogs.

Abstract: A beta-lactam antibiotic, amoxicillin, was microencapsulated with ethylcellulose using a solvent evaporation process in liquid paraffin containing sorbitan tristearate as a dispersing agent, and the microcapsules obtained showed first-order drug release.Usage of the previous log-log relationship of cefadroxil between in vitro dissolution half-lives (T50) and the experimental release rate constants (k'r) of the drug in vivo, and the nomogram for the design of satisfactory sustained-release preparations resulted in the prediction that ethylcellulose microcapsules containing 60% amoxicillin would show the most effective sustained-release pattern. Prepared microcapsules containing various amounts of amoxicillin were administered to beagle dogs and it was found that above prediction was correct. In addition, a more precise log-log correlation concerning amoxicilling was also undertaken, good linearity was observed and the decline was very similar to that of cefadroxil.

Liquid crystal combined film

Abstract: PURPOSE: To improve water resistance and to prevent the deterioration and change in properties of a liquid crystal and a dichroic dye by impregnating the liquid crystal or the liquid crystal and the dichroic dye into the communicating gap parts in a porous film of a three-dimensionally crosslinked structure and thereby forming the combined film. CONSTITUTION: This film is formed by emulsifying and crosslinking a mixture composed of an aq. water soluble polymer soln. and excess polyisocyanate or a mixture composed of an aq. water soluble polymer soln., the polyisocyanate and a high boiling compd., then removing the unreacted polyisocyanate or the high boiling compd. and impregnating the liquid crystal into the resulted water resistant porous film. The water soluble polymer is exemplified by polyvinyl alcohol and polypropylene glycol, the polyisocyanate by diisocyanate and triisocyanate and the high boiling compd. by, for example, liquid paraffin, octyl benzene, etc., which hardly evaporate at the time of crosslinking. The water resistance is improved in this way and the deterioration of the liquid crystal and the dichroic dye is prevented. COPYRIGHT: (C)1991,JPO&Japio

Preparation and Evaluation of Eudragit E Microspheres Containing Bacampicillin

Abstract: Microspheres with bacampicillin were prepared by the solvent evaporation method using systems methanol, acetone and methyl acetate/liquid paraffin and Eudragit E as polymer. Sieve analysis showed that the particle size of the microspheres follows log - normal distribution with average size of 123, 206 and 300 μm, respectively. Scanning electron microscopy was used to prove that all chosen systems provided the particles of regular spherical shape without aggregationHPLC method was developed for testing drug content, drug stability and dissolution. The results of HPLC analysis showed the exisistence of degradation products of bacampicillin in microspheres prepared by the use of all three solvents. The degree of degradation was the lowest in the case of methyl acetate. The experimental values of dissolution profiles fit well to 0. order and combined 0. and t½ order. The comparison of dissolution profiles of microspheres and bacampicillin itself shows that microspheres produce retard effect and theref...

Microcapsule agent and production thereof

Abstract: PURPOSE: To obtain a microcapsule agent having such function as to suppress medicinal degradation by digestive enzyme by encapsulating protease inhibitor and a medicinal substance in enteric microcapsules. CONSTITUTION: An acrylic acid resin derivative such as methacrylic acid-methyl methacrylate copolymer and hydroxypropylmethyl cellulose phthalate are dissolved in a solvent (pref. ethanol), and protease inhibitor and a medicinal substance (e.g. insulin, pentagastrin) degradable or deactivable in the presence of digestive enzyme are mixed with the resultant solution in this order and agitated followed by suspension into a viscous liquid such as liquid paraffin, glycerin or vegetable oil. Thence, an aqueous solution of gelatin and/or a viscous liquid suspended therewith is(are) added to the resulting suspension to effect separation of the objective microcapsule agent. Because of being enteric, the microcapsule agent can be protected from degradation due to pepsin in the stomach, and the medicinal substance can also be protected from degradation by trypsin and chymotrypsin through the action of the protease inhibitor when said substance dissolved out at the upper part of the small intestine. COPYRIGHT: (C)1990,JPO&Japio

Two-color thermal recording material

Abstract: PURPOSE: To obtain a two-color thermal recording material extremely excellent in the uniformity of the recording of a color forming layer by incorporating at least one kind of an org. polar compound type defoaming agent, a mineral oil type defoaming agent or a silicone resin type defoaming agent and at least one kind of a succinic aid type surfactant in a low temp. color forming layer. CONSTITUTION: A defoaming agent and a succinic acid type surfactant as a specific surfactant are contained in a coating solution for a low temp. color forming layer. As the defoaming agent, an org. polar compound type defoaming agent, a mineral oil type defoaming agent or a silicone resin type defoaming agent is designated. For example, as the org. polar compound type defoaming agent, sorbitan lauric acid monoester is designated and, as the mineral oil type defoaming agent, liquid paraffin is designated and, as the silicone resin type defoaming agent, dimethylsilicone oil is designated. As the succinic acid, sodium dimethylsulfosuccinate is used within a range of 0.1-20 rts.wt. per one pts.wt. of the defoaming agent. COPYRIGHT: (C)1991,JPO&Japio

Behavioural evidence for hygro‐ and mechanoreception by ovipositor sensilla of Dacus tryoni (Diptera: Tephritidae)

Abstract: . Gravid female Queensland fruit flies Dacus tryoni (Froggatt) readily oviposit when the ovipositor sensilla are stimulated either by a relatively thick (≥2 mm) surface layer, or by moisture under a relatively thin (<0.5 mm) or thick surface layer. A single layer of Parafilm over dry air elicits almost no oviposition; significantly more oviposition occurs when the underside of the Parafilm is coated with a 2 mm thick layer of petroleum jelly; even more oviposition occurs when the Parafilm is floated on liquid paraffin; greatest oviposition is elicited when moist media (agar gel, water or moist air) are presented under the Parafilm. Hollowed‐out domes of apple skin elicit significant oviposition only when sealed basally, to give high internal concentrations of water vapour. The previously identified groove sensilla on the tephritid ovipositor are inferred as being a source of mechanical and chemical information used by the fly in such ovipositional decisions. The ovipositor also has two other types of tactile sensilla. The three types of ovipositor sensilla of tephritids are considered to play roles analogous to those of certain labial receptors of flies with piercing mouthparts.

One paste-type restorative material

Abstract: PURPOSE:To obtain the title restorative material resistant to hardening during storage, having easy handleability such as dispensable even at a small amount and useful for dental and orthopedic use, etc., by mixing tricalcium alpha-phosphate powder, etc., with a specific kneading liquid and filling the obtained one-paste composition in a syringe. CONSTITUTION:Tricalcium alpha-phosphate powder, tetracalcium phosphate powder or a mixture of tetracalcium phosphate powder and other calcium phosphate powder is mixed with at least one kind of a kneading liquid selected from vegetable oil, polyhydric alcohol, polyalkylene glycol, silicone oil and liquid paraffin and the mixture is filled in a syringe. The ratio of the powder to the liquid is adjusted to get a paste having a viscosity of 1-1,000 poise. The above restorative material forms as excellent hardened hydroxyapatite in contact with water and the workability in operation can be improved. It can be used in dental field such as a root canal restoration intermediate material and pulp capping or in orthopedic field such as a bone cement and bone filler.

Preparation for use on the hair and body

Abstract: A preparation for use on the hair and body comprises a lotion including by weight 41 - 51 parts glycerine, 38 - 48 parts rosewater, 3 - 5 parts liquid paraffin and 2 - 4 parts olive oil.

Water-based erasable marking pen ink composition

Abstract: PURPOSE:To obtain the title composition which is freed of problems of toxicity and odor and can be easily peeled off simply by mildly rubbing the writing with a dry cloth or the like, by dispersing a normally liquid organic compound as a peeling agent in water as a solvent to form an aqueous emulsion and further adding a water-soluble resin to this emulsion. CONSTITUTION:An erasable marking pen ink composition is obtained by mixing water (A) as a solvent with a colorant (B) dissolved or dispersed in water, an emulsion (C) selected from among that of a normally liquid aliphatic carboxylic acid ester (e.g., propyl myristate or butyl stearate), that of a normally liquid higher hydrocarbon (e.g., liquid paraffin) or that of a normally liquid higher alcohol (e.g., octyl alcohol) and a water-soluble resin (D) (e.g., PVA of a degree of polymerization of 100-3000 and a degree of saponification >=50mol%). This composition is substantially free of problems of toxicity, odor and pungent odor encountered in a conventional oil-based ink composition and can be easily peeled and erased by mildly rubbing the writing with a dryl cloth, paper or the like.

Production of granular agricultural chemical

Abstract: PURPOSE: To obtain granular agricultural chemical having uniformly coated and suppressed peeling of active ingredient of agricultural chemical in using by mixing pulverized agricultural chemical of solid at normal temperature with non-volatile oil, making slurry and adding to oil-absorbing granular carrier. CONSTITUTION: Pulverized agricultural chemical solid at normal temperature is mixed with a non-volatile oil (especially spindle oil, machine oil or liquid paraffin) to obtain slurry. Then, said slurry is added to oil-absorbing granular carrier, thus the surface of individual single granule is uniformly coated with said agricultural chemical. Preferably, size of ≤98wt.% of total using solid agricultural chemical is desirably ≤63μm and especially, 80wt.% of whole granules is desirably ≤2μm. Besides, granules obtained by pelletizing with extrusion pelletizing of bentonite or talc, etc., uniformly mixed with humectant or binder, etc., as necessary, or granular pumice, etc., is used as the oil-absorbing granular carrier. COPYRIGHT: (C)1991,JPO&Japio

The choice of adjuvants in Mycoplasma vaccines.

Abstract: The use of adjuvants in vaccine production is an important aspect of potent vaccines. This investigation was concerned with finding the most efficient adjuvants for use in Mycoplasma vaccines produced in Nigeria. Four different vaccines were produced from the Gladysdale strain of Mycoplasma mycoides subspecies mycoides. They differed depending on the type of adjuvants used. Each vaccine was used to vaccinate eight cattle using a dose of 1 ml. Two other groups of eight cattle were used as controls. One of the two groups received 1 ml dose of inactivated Gladysdale vaccine without adjuvant while the second group received 1 ml dose of saline. The number of cattle that had the peak complement fixing (CF) antibody titres of 1/80 in each group of cattle was four for vaccine containing aluminium hydroxide gel, eight for vaccine containing liquid paraffin, one for vaccine containing sodium alginate and one for vaccine without adjuvant. Seven cattle from the group vaccinated with vaccine containing Freund's incomplete adjuvant had peak CF antibody titres of 1/80 or higher. The two groups vaccinated with vaccine containing liquid paraffin and Freund's incomplete adjuvant survived challenge at 6 months post vaccination. Freund's incomplete adjuvant and liquid paraffin containing 10% Arlacel A are the most efficient adjuvants.

Production of solid powder make-up cosmetic

Abstract: PURPOSE:To obtain the subject cosmetic having the merits such as the increased concentration of molded content, by mixing a volatile solvent to a powdery cosmetic base containing tetrafluoroethylene resin as an essential component, filling the mixture into a container in the form of slurry and removing the solvent to solidify the mixture CONSTITUTION:A powdery cosmetic base containing cosmetic powder (eg mica), an oil (eg liquid paraffin) and a tetrafluoroethylene resin as essential components is mixed with a volatile solvent (eg ethanol), the obtained slurry is filled in a container and the volatile solvent is removed to obtain the objective solidified cosmetic The amount of the tetrafluoroethylene resin is 001-50wt% in terms of resin concentration The cosmetic has improved strength of the molded content filled in the container, etc, and high impact resistance to enable the production of a thin or small-sized cosmetic Furthermore, it has various excellent characteristics; eg it can be applied to the skin without giving hard feeling and gives mild and soft feeling to the skin

Hair dyeing assistant for acid dye

Abstract: PURPOSE: To obtain the subject safe hair dyeing assistant for acid dyes containing one or more selected from squalene, squalane and partially hydro lyzed squalene as the essential components, having a low dermatopathy, provid ing a natural feeling and capable of improving the degree of dyeing. CONSTITUTION: One or more selected from squalene, squalane and partially hydrolyzed squalene are emulsified using one selected from a nonionic surfactant, a cationic surfactant and an amphoteric surfactant. An organic carboxylic acid (e.g. suocinic acid) is preferably added thereto in an amount of 0.01-0.5wt.% and the pH value of the resultant emulsified composition is adjusted to ≥3.0 and <7.0. A solvent (e.g. alcohol or liquid paraffin) is further added thereto as necessary to obtain the objective material. The above-mentioned surfactant is used in an amount of 1-200 pts.wt. based on 100 pts.wt. the above-mentioned one selected from squalene, etc. The resultant objective hair dye assistant can be used in a form of aqueous solution, emulsion, cream, paste, gel, etc. COPYRIGHT: (C)1991,JPO&Japio

Surface treating solution of molded fluorine-based resin product

Abstract: PURPOSE: To obtain the subject treating solution capable of exhibiting well- balanced treating effects, operating efficiency, stability, economical efficiency and storability by adding a specific aluminum compound and liquid paraffin to a solution containing a complex of Na with naphthalene. CONSTITUTION: A surface treating solution for molded fluorine-based resin products obtained by dissolving a complex of sodium with naphthalene is ethylene glycol.dimethyl ether and/or butylene glycol.dimethyl ether to provide a solution and blending aluminum distearate and/or aluminum monostearate and liquid paraffin therewith. The amounts of the added components based on 100g sodium dispersion of the naphthalene medium are within the range of 500-1000ml ethylene glycol.dimethyl ether, 0.5-10g aluminum distearate and 5-50g liquid paraffin. COPYRIGHT: (C)1990,JPO&Japio

Porous hollow yarn membrane, production thereof and artificial lung utilizing said hollow yarn membrane

Abstract: PURPOSE:To obtain a hollow yarn membrane high in gas-liquid contact efficiency by forming the inner surface of the membrane of a continuous phase consisting of granular PP and forming both the inside and the outer surface of the membrane of PP lumps and regulating the breaking strength, mean crimping amplitude, the ratio of maximum crimping amplitude to crimping semicycle at a time of maximum crimping amplitude and percentage crimp to the specified value. CONSTITUTION:The admixture consisting of PP, an organic fiber such as liquid paraffin and a crystalline nucleus forming agent such as dibenzylidene sorbitol is discharged hollow through an annular spinning hole and brought into contact with cooling and solidifying liquid to cool and solidifying it and thereafter brought into contact with extract to extract and remove the organic filler. Then this hollow yarn membrane is stretched at 1-30% and heat- treated and thereafter wound into cross winding on a bobbin and furthermore thermally fixed in an oven and crimped. By such a way, the porous hollow yarn membrane in which the axial breaking strength is regulated to 80g/yarn or more and mean crimping amplitude is regulated to 35-120% of the outer diameter of the membrane and the ratio of maximum crimping amplitude to crimping semicycle at a time of maximum crimping amplitude is regulated to 0.01-0.1 and percentage crimp is 1.0-3.0% and gas exchange capacity is made large is obtained.

Percutaneously absorbable preparation of ketotifen

Abstract: PURPOSE: To provide the subject preparation capable of maintaining a high blood concentration of the subject drug for a long time despite the application within a small area by adding the drug and liquid paraffin and/or silicon oil as absorption-accelerating agents in specific amounts, respectively, to a specific tackifier layer on a support. CONSTITUTION: A tackifier layer containing 1-42wt.% of 4-(1-methyl-4- peperidylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophene-10(9H)-on and/or a salt thereof useful as a treating agent of allergic diseases and further containing (A) liquid paraffin and/or (B) a silicone oil in a ratio of A=1-300 pts.wt. : B=1-200 pts.wt. based on 100 pts.wt. of the tackifier base material is disposed on a drug-impermeable, flexible support to provide a percutaneous absorbable preparation of ketotifen having high skin permeability of the drug, sustained releasing property, high treating ability, excellent safety and good adhesivity. COPYRIGHT: (C)1991,JPO&Japio

Microemulsion formulation and production thereof

Abstract: PURPOSE: To obtain microemulsion agent having excellent stability and percutaneous absorption property by combining crotamiton, oil having specific IOB and hydrophilic surfactant in a constant mixing ratio and emulsifying indomethacin together with water. CONSTITUTION: Indomethacin (0.05-3.0wt.%) is dissolved in crotamiton (0.5-10.0wt.%) with heating and oil having 0-0.3 IOB (e.g. triglyceride or liquid paraffin) in an amount of 1/20-10 times of total amount of indomethacin and crotamiton and other oil component are added to prepare oil phase. On the other hand, hydrophilic surfactant (especially 0.1-15.0wt.% nonionic surfactant is suitable) and other aqueous component are added and dissolved with heating, then water is added thereto to prepare water phase. Next, the water phase ls stirred with adding of the oil phase and emulsified to produce indomethacin- containing microemulsion formulation. Resultant formulation has exceedingly fine diameter of emulsified particles. COPYRIGHT: (C)1991,JPO&Japio