Adolf Graessmann

TL;DR: Results indicate that recruitment of histone acetyltransferase activity of PCAF by MyoD, through p300/CBP, is crucial for activation of the myogenic program.

TL;DR: It is demonstrated that, in differentiating skeletal muscle cells, p300 physically interacts with the myogenic basic helix–loop–helix (bHLH) regulatory protein MyoD at its DNA binding sites, and p300 potentiates MyOD‐ and myogenin‐dependent activation of transcription from E‐box‐containing reporter genes.

TL;DR: The data indicate that the different specificities exhibited by Tag and E1a towards the various forms of p300 are reflected in vivo as a difference in the ability of these viral oncoproteins to modulate the expression of CRE‐containing genes.

TL;DR: It is demonstrated for the first time that the hepatitis B virus-encoded HBx is a potent caspase 3 inhibitor, and gene dissection experiments revealed that the regions required for the anti-caspase activity overlap with the two known transactivation domains of HBx.

TL;DR: The histones were also able to mediate penetration of covalently attached bovine serum albumin (BSA) molecules, indicating their potential as carriers for the delivery of macromolecules into living mammalian cells.