Differential roles of p300 and PCAF acetyltransferases in muscle differentiation
Pier Lorenzo Puri,Pier Lorenzo Puri,Vittorio Sartorelli,Vittorio Sartorelli,Xiang Jiao Yang,Yasuo Hamamori,Vasily Ogryzko,Bruce H. Howard,Larry Kedes,Jean Y. J. Wang,Adolf Graessmann,Yoshihiro Nakatani,Massimo Levrero,Massimo Levrero +13 more
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TLDR
Results indicate that recruitment of histone acetyltransferase activity of PCAF by MyoD, through p300/CBP, is crucial for activation of the myogenic program.About:
This article is published in Molecular Cell.The article was published on 1997-12-01 and is currently open access. It has received 426 citations till now. The article focuses on the topics: PCAF & Histone acetyltransferase activity.read more
Citations
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The coregulator exchange in transcriptional functions of nuclear receptors
TL;DR: Based on their importance in biology and medicine, as well as the relatively simple mechanism of regulation, NR represent one of the most intensively studied and best-understood classes of transcription factors at the molecular level.
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Acetylation of Histones and Transcription-Related Factors
TL;DR: This work detail these known factor acetyltransferase (FAT) substrates and the demonstrated or potential roles of their acetylation in transcriptional processes.
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Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms.
Mark Eben Massari,Cornelis Murre +1 more
TL;DR: The helix-loop-helix (HLH) family of transcriptional regulatory proteins are key players in a wide array of developmental processes, including neurogenesis, myogenesis, hematopoiesis, and pancreatic development and the structure and functional properties are examined.
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CBP/p300 in cell growth, transformation, and development
TL;DR: This review focuses on the involvement of CBP/p300 in the complex biological processes that affect cell growth, transformation, and development.
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Structure and ligand of a histone acetyltransferase bromodomain
TL;DR: The solution structure of the bromodomain of the HAT co-activator P/CAF (p300/CBP-associated factor) reveals an unusual left-handed up-and-down four-helix bundle, and it is shown by a combination of structural and site-directed mutagenesis studies that bromidomains can interact specifically with acetylated lysine, making them the first known protein modules to do so.
References
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WAF1, a potential mediator of p53 tumor suppression
Wafik S. El-Deiry,Takashi Tokino,Victor E. Velculescu,Daniel B. Levy,Ramon Parsons,Jeffrey M. Trent,D Lin,W. Edward Mercer,Kenneth W. Kinzler,Bert Vogelstein +9 more
TL;DR: A gene is identified, named WAF1, whose induction was associated with wild-type but not mutant p53 gene expression in a human brain tumor cell line and that could be an important mediator of p53-dependent tumor growth suppression.
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The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases
TL;DR: It is demonstrated that p300/CBP acetylates nucleosomes in concert with PCAF, a novel class of acetyltransferases in that it does not have the conserved motif found among various other acetyl transferases.
Journal ArticleDOI
Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain
Wei Gu,Robert G. Roeder +1 more
TL;DR: It is demonstrated that p53 can be modified by acetylated both in vivo and in vitro, indicating a novel pathway for p53 activation and providing an example of an acetylation-mediated change in the function of a nonhistone regulatory protein.
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The CBP co-activator is a histone acetyltransferase
TL;DR: It is shown that CBP has intrinsic HAT activity, and Targeting CBP-associated H AT activity to specific promoters may be a mechanism by which E1A acts as a transcriptional activator.
Journal ArticleDOI
MyoD or Myf-5 is required for the formation of skeletal muscle
Michael A. Rudnicki,Patrick N. J. Schnegelsberg,R. H. Stead,Thomas Braun,Hans-Henning Arnold,Rudolf Jaenisch +5 more
TL;DR: Observations suggest that either Myf-5 or MyoD is required for the determination of skeletal myoblasts, their propagation, or both during embryonic development and indicate that these factors play, at least in part, functionally redundant roles in myogenesis.
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Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain
Wei Gu,Robert G. Roeder +1 more