Adrienne O’Donnell

TL;DR: In this paper, the authors detected initial cortical emergence of tauopathy near the rhinal sulcus in clinically normal people and tracked Aβ-associated spread of TAU from this site first to nearby neocortex of the temporal lobe and then to extratemporal regions.

TL;DR: In this article, the authors examined the association of individual forms of social support with a global neuroanatomical measure of early ADRD vulnerability and cognition, and found that high listener availability was associated with greater cognitive resilience, independently modifying the association between lower total cerebral volume and poorer cognitive function.

TL;DR: Loneliness was associated with increased dementia risk over 10 years of close clinical dementia surveillance in this cohort study; this tripled in adults whose baseline risk would otherwise be relatively low on the basis of age and genetic risk.

TL;DR: In this article, the authors evaluated whether adherence to the Mediterranean-DASH for Neurodegenerative Delay (MIND) diet associated with superior cognitive function, larger brain volumes, fewer SBIs, and less cognitive decline in the community-based Framingham Heart Study.

TL;DR: The results highlight hypertension having a major role in subclinical CSVD, across subtypes and brain regions, and call attention to improve recognition and treatment of hypertension early in life.