M
Michael J. Properzi
Researcher at Harvard University
Publications - 57
Citations - 1694
Michael J. Properzi is an academic researcher from Harvard University. The author has contributed to research in topics: Cognitive decline & Medicine. The author has an hindex of 13, co-authored 37 publications receiving 836 citations.
Papers
More filters
Journal ArticleDOI
Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults.
Rachel F. Buckley,Elizabeth C. Mormino,Jennifer S. Rabin,Timothy J. Hohman,Susan M. Landau,Bernard Hanseeuw,Bernard Hanseeuw,Heidi I.L. Jacobs,Heidi I.L. Jacobs,Kathryn V. Papp,Kathryn V. Papp,Rebecca E. Amariglio,Rebecca E. Amariglio,Michael J. Properzi,Aaron P. Schultz,Aaron P. Schultz,Dylan Kirn,Dylan Kirn,Matthew R. Scott,Trey Hedden,Michelle E. Farrell,Julie C. Price,Jasmeer P. Chhatwal,Jasmeer P. Chhatwal,Dorene M. Rentz,Dorene M. Rentz,Victor L. Villemagne,Keith A. Johnson,Keith A. Johnson,Reisa A. Sperling,Reisa A. Sperling +30 more
TL;DR: Early tau deposition was elevated in women compared with men in individuals on the Alzheimer disease trajectory, and this findings lend support to a growing body of literature that highlights a biological underpinning for sex differences in Alzheimer disease risk.
Journal ArticleDOI
Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts.
Rachel F. Buckley,Elizabeth C. Mormino,Rebecca E. Amariglio,Rebecca E. Amariglio,Michael J. Properzi,Jennifer S. Rabin,Yen Ying Lim,Kathryn V. Papp,Kathryn V. Papp,Heidi I.L. Jacobs,Heidi I.L. Jacobs,Samantha C. Burnham,Bernard Hanseeuw,Bernard Hanseeuw,Bernard Hanseeuw,Vincent Dore,Annette J. Dobson,Colin L. Masters,Michael Waller,Christopher C. Rowe,Paul Maruff,Michael C. Donohue,Dorene M. Rentz,Dorene M. Rentz,Dylan Kirn,Dylan Kirn,Trey Hedden,Jasmeer P. Chhatwal,Aaron P. Schultz,Aaron P. Schultz,Keith A. Johnson,Victor L. Villemagne,Reisa A. Sperling,Reisa A. Sperling +33 more
TL;DR: The objective was to investigate the effect of sex on cognitive decline within the context of amyloid β burden and apolipoprotein E genotype.
Journal ArticleDOI
Interactive Associations of Vascular Risk and β-Amyloid Burden With Cognitive Decline in Clinically Normal Elderly Individuals: Findings From the Harvard Aging Brain Study.
Jennifer S. Rabin,Aaron P. Schultz,Trey Hedden,Anand Viswanathan,Gad A. Marshall,Gad A. Marshall,Emily P. Kilpatrick,Hannah Klein,Rachel F. Buckley,Rachel F. Buckley,Rachel F. Buckley,Hyun-Sik Yang,Hyun-Sik Yang,Michael J. Properzi,Vaishnavi Rao,Dylan Kirn,Kathryn V. Papp,Kathryn V. Papp,Dorene M. Rentz,Dorene M. Rentz,Keith A. Johnson,Reisa A. Sperling,Reisa A. Sperling,Jasmeer P. Chhatwal +23 more
TL;DR: Vascular risk was associated with prospective cognitive decline in clinically normal older adults, both alone and synergistically with A&bgr; burden, and may complement imaging biomarkers in assessing risk of prospective Cognitive decline in preclinical Alzheimer disease.
Journal ArticleDOI
The impact of amyloid-beta and tau on prospective cognitive decline in older individuals
Reisa A. Sperling,Reisa A. Sperling,Elizabeth C. Mormino,Elizabeth C. Mormino,Aaron P. Schultz,Rebecca A. Betensky,Kathryn V. Papp,Kathryn V. Papp,Rebecca E. Amariglio,Rebecca E. Amariglio,Bernard Hanseeuw,Rachel F. Buckley,Rachel F. Buckley,Jasmeer P. Chhatwal,Trey Hedden,Gad A. Marshall,Gad A. Marshall,Yakeel T. Quiroz,Nancy J. Donovan,Nancy J. Donovan,Jonathan D. Jackson,Jennifer R. Gatchel,Jennifer S. Rabin,Heidi I.L. Jacobs,Hyun-Sik Yang,Hyun-Sik Yang,Michael J. Properzi,Dylan Kirn,Dorene M. Rentz,Dorene M. Rentz,Keith A. Johnson +30 more
TL;DR: Amyloid‐beta and tau pathologies are commonly observed among clinically normal older individuals at postmortem and can now be detected with in vivo neuroimaging and the association and interaction of these proteinopathies with prospective cognitive decline in normal aging and preclinical Alzheimer's disease remains to be fully elucidated.
Journal ArticleDOI
Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global β-Amyloid Burden.
Rachel F. Buckley,Bernard Hanseeuw,Bernard Hanseeuw,Aaron P. Schultz,Patrizia Vannini,Sarah L. Aghjayan,Michael J. Properzi,Jonathan D. Jackson,Jonathan D. Jackson,Elizabeth C. Mormino,Dorene M. Rentz,Dorene M. Rentz,Reisa A. Sperling,Reisa A. Sperling,Keith A. Johnson,Rebecca E. Amariglio,Rebecca E. Amariglio +16 more
TL;DR: Subjective cognitive decline is indicative of accumulation of early tauopathy in the medial temporal lobe, specifically in the entorhinal cortex, and to a lesser extent, elevated global levels of A&bgr;.