S
Sicong Zhang
Researcher at University of Texas MD Anderson Cancer Center
Publications - 19
Citations - 2085
Sicong Zhang is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Carcinogenesis & Regulation of gene expression. The author has an hindex of 14, co-authored 17 publications receiving 1275 citations. Previous affiliations of Sicong Zhang include University of Texas at Austin & Rockefeller University.
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Journal ArticleDOI
m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program.
Sicong Zhang,Boxuan Simen Zhao,Aidong Zhou,Kangyu Lin,Shaoping Zheng,Zhike Lu,Zhike Lu,Yaohui Chen,Erik P. Sulman,Keping Xie,Oliver Bogler,Sadhan Majumder,Chuan He,Suyun Huang +13 more
TL;DR: This work uncovers a critical function for ALKBH5 and provides insight into critical roles of m6A methylation in glioblastoma and a long non-coding RNA antisense to FOXM1 (FOXM1-AS) promotes the interaction of AL KBH5 withFOXM1 nascent transcripts.
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YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis
Guoqiang Chang,Lei Shi,Youqiong Ye,Hailing Shi,Hailing Shi,Lixian Zeng,Shweta Tiwary,Jason T. Huse,Lei Huo,Li Ma,Yongjie Ma,Sicong Zhang,Jianwei Zhu,Victoria Xie,Peng Li,Leng Han,Chuan He,Chuan He,Suyun Huang,Suyun Huang +19 more
TL;DR: This work uncovers an essential role of YTHDF3 in controlling the interaction between cancer cells and brain microenvironment, thereby inducing brain metastatic competence.
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EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma.
Runping Fang,Xin Chen,Sicong Zhang,Hui Shi,Youqiong Ye,Hailing Shi,Hailing Shi,Zhongyu Zou,Zhongyu Zou,Peng Li,Qing Guo,Li Ma,Chuan He,Suyun Huang,Suyun Huang +14 more
TL;DR: In this paper, the authors show that YTHDF2 overexpression correlates with poor glioma patient prognosis and highlight the essential role of RNA m6A methylation in cholesterol homeostasis.
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Mechanosensitive pannexin-1 channels mediate microvascular metastatic cell survival
Furlow Pw,Sicong Zhang,Soong Td,Nils Halberg,Hani Goodarzi,Mangrum C,Wu Yg,Olivier Elemento,Sohail F. Tavazoie +8 more
TL;DR: A mutation encoding a truncated form of the pannexin-1 (PANX1) channel, PANX11–89, is identified as recurrently enriched in highly metastatic breast cancer cells, suggesting a molecular basis for metastatic cell survival on microvasculature-induced biomechanical trauma.
Journal ArticleDOI
Tumour suppressor TRIM33 targets nuclear β-catenin degradation
Jianfei Xue,Yaohui Chen,Yamei Wu,Zhongyong Wang,Aidong Zhou,Sicong Zhang,Kangyu Lin,Kenneth Aldape,Sadhan Majumder,Zhimin Lu,Suyun Huang +10 more
TL;DR: It is demonstrated that tripartite motif-containing protein 33 (TRIM33), acting as an E3 ubiquitin ligase, reduces the abundance of nuclear β-catenin protein.