Akihiko Kimura

TL;DR: Two deletions and a missense mutation in the active transport family signature region in the gene in patients with hyperbilirubinemia II/Dubin‐Johnson syndrome (DJS) are reported, which strongly implicate the cMOAT gene as responsible for the defects in DJS patients.

TL;DR: The majority of children with CHC presented with mild fibrosis, but a few showed CHC with lobular distortion and hemosiderosis, and frequent blood transfusion may aggravate hepatic lesions in pediatric CHC.

TL;DR: The results indicate that specific cholestenoic acids selectively work on motor neurons, via LXR, to regulate the balance between survival and death.

TL;DR: Six patients with Byler's disease developed intractable diarrhea after living donor liver transplantation, and four patients were treated with bile acid adsorptive resin for bile Acid diarrhea, and all showed improved bowel movements.

TL;DR: It is suggested that chenodeoxycholic acid (CDCA) can reduce the activity of cholesterol 27-hydroxylase - the first step in the acidic pathway for bile acid synthesis.