L
Ludger Schöls
Researcher at University of Tübingen
Publications - 391
Citations - 17866
Ludger Schöls is an academic researcher from University of Tübingen. The author has contributed to research in topics: Ataxia & Spinocerebellar ataxia. The author has an hindex of 67, co-authored 338 publications receiving 14915 citations. Previous affiliations of Ludger Schöls include German Center for Neurodegenerative Diseases & Goethe University Frankfurt.
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Journal ArticleDOI
Autosomal dominant cerebellar ataxias: clinical features, genetics, and pathogenesis.
TL;DR: The identification of ataxia genes raises hope that essential pathogenetic mechanisms causing SCA will become more and more apparent, and will enable the development of rational therapies for this group of disorders, which currently can only be treated symptomatically.
MonographDOI
Leitlinien für Diagnostik und Therapie in der Neurologie
H. C. Diener,C. Weimar,P. Berlit,Günther Deuschl,Christian E. Elger,R. Gold,Werner Hacke,A. Hufschmidt,Heinrich Mattle,U. Meier,W. H. Oertel,H. Reichmann,E. Schmutzhard,Claus-W. Wallesch,M. Weller,Hermann Ackermann,Gabriele Arendt,Ralf Baron,Helmuth Steinmetz,Peter-Dirk Berlit,Christian Bien,F. Birklein,Armin Curt,Marcus Deschauer,Génther Deuschl,Rolf R. Diehl,Hans-Christoph Diener,Marianne Dieterich,Karla Eggert,Christian E. Elger,Matthias Endres,Stefanie Förderreuther,Christian Gerloff,Franz Xaver Glocker,Ralf Gold,Gerhard F. Hamann,Josef Georg Heckmann,Michael G. Hennerici,Wieland Hermann,Stefan Hesse,Dieter Heuß,Wolfgang Jost,Eric Jéttler,Reinhard Kaiser,Hans-Otto Karnath,Oliver Kastrup,Thomas Klockgether,Cornelia Kornblum,Frank Lehmann-Horn,Heinz Reichmann,Frank Leypoldt,Joachim Liepert,Rainer Lindemuth,Albert C. Ludolph,Matthias Maschke,Arne May,Geert Mayer,Hans-Michael Meinck,Uta Meyding-Lamadü,Sandra Verena Méller,Kirsten Méller-Vahl,Roland Nau,Gereon Nelles,W. H. Oertel,Walter Paulus,Hans-Walter Pfister,Marcus Pohl,Mario Prosiegel,Sebastian Rauer,E. Bernd Ringelstein,Felix Rosenow,Carsten Saft,Dirk Sander,Konrad Scheglmann,Uwe Schlegel,Erich Schmutzhard,Christiane Schneider-Gold,Ludger Schöls,Paul W. Schönle,Jörg B. Schulz,Claudia Sommer,Thorsten Steiner,Andreas Straubev,Dominik Straumann,Michael Strupp,Walter Sturm,Martin Tegenthoff,Eckhard Thiel,Angelika Thöne-Otto,Claudia Trenkwalder,Wolfram Ziegler,Roland Veltkamp,Jens Volkmann,Gunnar Wasner,Jörg R. Weber,Christian Weimar,Michael Weller,Heinz Wiendl,Dirk Woitalla,Ullrich Wéllner,Inga Zerr,Josef Zihl +101 more
Journal ArticleDOI
The natural history of degenerative ataxia: a retrospective study in 466 patients.
Thomas Klockgether,R. Lüdtke,Bernd Krämer,Michael Abele,Katrin Bürk,Ludger Schöls,Olaf Riess,Franco Laccone,S Boesch,Iscia Lopes-Cendes,Alexis Brice,Rivka Inzelberg,N Zilber,Johannes Dichgans +13 more
TL;DR: In FRDA, the time until confinement to wheelchair was shorter in patients with earlier disease onset, suggesting that patients with long GAA repeats and early disease onset have a poor prognosis, and in MSA, later age of onset increased the risk of rapid progression and death.
Journal ArticleDOI
Oxidative stress in patients with Friedreich ataxia
Jörg B. Schulz,Thomas Dehmer,Ludger Schöls,H. Mende,C Hardt,Matthias Vorgerd,Katrin Bürk,Wayne R. Matson,Johannes Dichgans,M F Beal,M B Bogdanov +10 more
TL;DR: Oral treatment with 5 mg/kg/day of the antioxidant idebenone for 8 weeks significantly decreased urinary 8OH2'dG concentrations, indicating that 8OH 2'dG may be useful in monitoring therapeutic interventions in patients with FRDA.
Journal ArticleDOI
A Pan‐European Study of the C9orf72 Repeat Associated with FTLD: Geographic Prevalence, Genomic Instability, and Intermediate Repeats
Julie van der Zee,Ilse Gijselinck,Lubina Dillen,Tim Van Langenhove,Jessie Theuns,Sebastiaan Engelborghs,Stéphanie Philtjens,Mathieu Vandenbulcke,Kristel Sleegers,Anne Sieben,Anne Sieben,Veerle Bäumer,Githa Maes,Ellen Corsmit,Barbara Borroni,Alessandro Padovani,Silvana Archetti,Robert Perneczky,Janine Diehl-Schmid,Alexandre de Mendonça,Gabriel Miltenberger-Miltenyi,Sónia Pereira,José Pimentel,Benedetta Nacmias,Silvia Bagnoli,Sandro Sorbi,Caroline Graff,Caroline Graff,Huei-Hsin Chiang,Marie Westerlund,Raquel Sánchez-Valle,Albert Lladó,Ellen Gelpi,Isabel Santana,Maria Rosário Almeida,Beatriz Santiago,Giovanni B. Frisoni,Orazio Zanetti,Cristian Bonvicini,Matthis Synofzik,Walter Maetzler,Jennifer Müller vom Hagen,Ludger Schöls,Michael T. Heneka,Michael T. Heneka,Frank Jessen,Frank Jessen,Radoslav Matej,Eva Parobkova,Gabor G. Kovacs,Thomas Ströbel,Stayko Sarafov,Ivailo Tournev,Ivailo Tournev,Albena Jordanova,Adrian Danek,Thomas Arzberger,Gian Maria Fabrizi,Silvia Testi,Eric Salmon,Patrick Santens,Jean-Jacques Martin,Patrick Cras,Rik Vandenberghe,Peter Paul De Deyn,Marc Cruts,Christine Van Broeckhoven,Peter Paul De Deyn,Alfredo Ramirez,Delia Kurzwelly,Carmen Sachtleben,Wolfgang Mairer,Clara Firmo,Anna Antonell,José Luis Molinuevo,Anne Kinhult Ståhlbom,Håkan Thonberg,Inger Nennesmo,Anne Börjesson-Hanson,Valentina Bessi,Irene Piaceri,Maria Helena Ribeiro,Catarina R. Oliveira,João Massano,Carolina Garret,Paula Pires,Adrian Danel,Sergio Ferrari,Tiziana Cavallaro +88 more
TL;DR: In vitro reporter gene expression studies demonstrated significantly decreased transcriptional activity of C9orf72 with increasing number of normal repeat units, indicating that intermediate repeats might act as predisposing alleles and in favor of the loss‐of‐function disease mechanism.