J
Jens Kuhle
Researcher at University Hospital of Basel
Publications - 389
Citations - 18287
Jens Kuhle is an academic researcher from University Hospital of Basel. The author has contributed to research in topics: Medicine & Multiple sclerosis. The author has an hindex of 57, co-authored 280 publications receiving 11767 citations. Previous affiliations of Jens Kuhle include University of Melbourne & National Multiple Sclerosis Society.
Papers
More filters
Journal ArticleDOI
Neurofilaments as biomarkers in neurological disorders
Michael Khalil,Charlotte E. Teunissen,Markus Otto,Fredrik Piehl,Maria Pia Sormani,Thomas Gattringer,Christian Barro,Ludwig Kappos,Manuel Comabella,Franz Fazekas,Axel Petzold,Kaj Blennow,Kaj Blennow,Henrik Zetterberg,Jens Kuhle +14 more
TL;DR: How technological advances have enabled the detection of neurofilament proteins in the blood is considered, and how these proteins consequently have the potential to be easily measured biomarkers of neuroaxonal injury in various neurological conditions are discussed.
Journal ArticleDOI
Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis.
Giulio Disanto,Christian Barro,Pascal Benkert,Yvonne Naegelin,Sabine Schädelin,Antonella Giardiello,Chiara Zecca,Kaj Blennow,Henrik Zetterberg,David Leppert,Ludwig Kappos,Claudio Gobbi,Jens Kuhle +12 more
TL;DR: The value of an ultrasensitive single‐molecule array (Simoa) serum NfL (sNfL) assay in multiple sclerosis (MS) is explored.
Journal ArticleDOI
Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis
Kjetil Bjornevik,Marianna Cortese,Brian C. Healy,Jens Kuhle,Michael J. Mina,Yumei Leng,Stephen J. Elledge,David W. Niebuhr,Ann I. Scher,Kassandra L. Munger,Alberto Ascherio +10 more
TL;DR: It is determined that Epstein-Barr virus infection greatly increased the risk of subsequent multiple sclerosis and that it preceded the development of disease, supporting its potential role in the pathogenesis of multiple sclerosis.
Journal ArticleDOI
A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking
Charlotte E. Teunissen,Axel Petzold,Jeffrey Bennett,Frode S. Berven,Lou Brundin,Manuel Comabella,Diego Franciotta,Jette L. Frederiksen,John O. Fleming,Roberto Furlan,Rogier Q. Hintzen,S Hughes,M. H. Johnson,Eva Krasulova,Jens Kuhle,Maria Chiara Magnone,Cecilia Rajda,Konrad Rejdak,Hollie Schmidt,Vincent Van Pesch,Emmanuelle Waubant,Christian Wolf,Gavin Giovannoni,Bernhard Hemmer,Hayrettin Tumani,Florian Deisenhammer +25 more
TL;DR: A consensus report on recommendations for CSF collection and biobanking is presented, formed by the BioMS-eu network forCSF biomarker research in multiple sclerosis, and focuses on CSf collection procedures, preanalytical factors, and high-quality clinical and paraclinical information.
Journal ArticleDOI
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease
Oliver Preische,Oliver Preische,Stephanie A. Schultz,Anja Apel,Anja Apel,Jens Kuhle,Stephan A. Kaeser,Stephan A. Kaeser,Christian Barro,Susanne Gräber,Elke Kuder-Buletta,Christian LaFougere,Christoph Laske,Christoph Laske,Jonathan Vöglein,Jonathan Vöglein,Johannes Levin,Johannes Levin,Colin L. Masters,Ralph N. Martins,Peter R. Schofield,Peter R. Schofield,Martin N. Rossor,Neill R. Graff-Radford,Stephen Salloway,Bernardino Ghetti,John M. Ringman,James M. Noble,Jasmeer P. Chhatwal,Alison Goate,Tammie L.S. Benzinger,John C. Morris,Randall J. Bateman,Guoqiao Wang,Anne M. Fagan,Eric McDade,Brian A. Gordon,Mathias Jucker,Mathias Jucker +38 more
TL;DR: Serum NfL dynamics in serum predict disease progression and brain neurodegeneration at the early presymptomatic stages of familial Alzheimer’s disease, which supports its potential utility as a clinically useful biomarker.