Michael R. Drew

TL;DR: A mouse model of an anxiety/depressive-like state induced by chronic corticosterone treatment is described, and mice deficient in one of these genes, beta-arrestin 2, displayed a reduced response to fluoxetine in multiple tasks, suggesting that beta-Arrestin signaling is necessary for the antidepressant effects of fluoxettine.

TL;DR: The findings show that adult-born neurons make a distinct contribution to some but not all hippocampal functions and show that new hippocampal neurons can be preferentially recruited over mature granule cells in vitro and may provide a framework for how this small cell population can influence behavior.

TL;DR: It is reported that environmental enrichment alters behavior in mice regardless of their hippocampal neurogenic capability, providing evidence that the newborn cells do not mediate these effects of enrichment.

TL;DR: It is suggested that early D2 overexpression alters the organization of interval timing circuits and confirms that striatal D2 signaling in the adult regulates motivational process, as well as under pathological conditions such as schizophrenia and Parkinson's disease.

TL;DR: It is suggested that the transient enhancement of plasticity observed in young adult‐born neurons contributes to cognitive functions in mice after neurogenesis was arrested using focal x‐irradiation of the hippocampus or a reversible method in which glial fibrillary acidic protein‐positive neural progenitor cells are ablated with ganciclovir.