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Aleksandra Trifunovic
Researcher at University of Cologne
Publications - 94
Citations - 9155
Aleksandra Trifunovic is an academic researcher from University of Cologne. The author has contributed to research in topics: Mitochondrion & Mitochondrial DNA. The author has an hindex of 30, co-authored 80 publications receiving 7840 citations. Previous affiliations of Aleksandra Trifunovic include Max Planck Society & Karolinska Institutet.
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Premature ageing in mice expressing defective mitochondrial DNA polymerase
Aleksandra Trifunovic,Anna Wredenberg,Maria Falkenberg,Johannes N. Spelbrink,Anja T. Rovio,Carl E.G. Bruder,Mohammad Bohlooly-Y,Sebastian Gidlöf,Anders Oldfors,Rolf Wibom,Jan Törnell,Howard T. Jacobs,Nils-Göran Larsson +12 more
TL;DR: The results provide a causative link between mtDNA mutations and ageing phenotypes in mammals by creating homozygous knock-in mice that express a proof-reading-deficient version of PolgA, the nucleus-encoded catalytic subunit of mtDNA polymerase.
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Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA
Maria Falkenberg,Martina Gaspari,Anja Rantanen,Aleksandra Trifunovic,Nils-Göran Larsson,Claes M. Gustafsson +5 more
TL;DR: The presence of two proteins that interact with mammalian POLRMT may allow flexible regulation of mtDNA gene expression in response to the complex physiological demands of mammalian metabolism.
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Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production
Aleksandra Trifunovic,Anna Hansson,Anna Wredenberg,Anja T. Rovio,Eric Dufour,Ivan Khvorostov,Johannes N. Spelbrink,Rolf Wibom,Howard T. Jacobs,Nils-Göran Larsson +9 more
TL;DR: The premature aging phenotypes in mt DNA mutator mice are thus not generated by a vicious cycle of massively increased oxidative stress accompanied by exponential accumulation of mtDNA mutations, and it is proposed that respiratory chain dysfunction per se is the primary inducer of premature aging in mtDNA mutATOR mice.
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Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons.
Mats I. Ekstrand,Mügen Terzioglu,Dagmar Galter,Shunwei Zhu,Christoph P. Hofstetter,Eva Lindqvist,Sebastian Thams,Anita Bergstrand,Fredrik Sterky Hansson,Aleksandra Trifunovic,Barry J. Hoffer,Staffan Cullheim,Abdul H. Mohammed,Lars Olson,Nils-Göran Larsson +14 more
TL;DR: It is demonstrated that respiratory chain dysfunction in DA neurons may be of pathophysiological importance in PD and reduced mtDNA expression and respiratory chain deficiency in midbrain DA neurons leads to a parkinsonism phenotype.
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Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance.
Sarah M. Turpin,Hayley T. Nicholls,Diana M. Willmes,Arnaud Mourier,Susanne Brodesser,Claudia M. Wunderlich,Jan Mauer,Elaine Xu,Philipp Hammerschmidt,Hella S. Brönneke,Aleksandra Trifunovic,Giuseppe LoSasso,F. Thomas Wunderlich,Jan-Wilhelm Kornfeld,Matthias Blüher,Martin Krönke,Jens C. Brüning +16 more
TL;DR: CerS6 inhibition is highlighted as a specific approach for the treatment of obesity and type 2 diabetes mellitus, circumventing the side effects of global ceramide synthesis inhibition.