A
Aleš Linhart
Researcher at First Faculty of Medicine, Charles University in Prague
Publications - 371
Citations - 36568
Aleš Linhart is an academic researcher from First Faculty of Medicine, Charles University in Prague. The author has contributed to research in topics: Fabry disease & Medicine. The author has an hindex of 50, co-authored 333 publications receiving 30467 citations. Previous affiliations of Aleš Linhart include University Hospital of Wales & Charles University in Prague.
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Journal ArticleDOI
Study of urinary proteomes in Anderson-Fabry disease
Lucie Vojtova,Tomáš Zima,Vladimír Tesař,Jana Michalova,Petr Přikryl,Gabriela Dostálová,Aleš Linhart +6 more
TL;DR: AFD urinary proteomics revealed increased secretion of several proteins and it is postulated that the observed difference in the amount of prostaglandin H2 d-isomerase and its position on two-dimensional gels might be related to different glycosylation in AFD subjects.
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Older age and type of surgery predict the early inflammatory response to hip trauma mediated by interleukin-6 (IL-6).
Martin Sedlář,Zuzana Kudrnová,David Erhart,S Trca,Jan Kvasnička,Z Krska,Jiří Mazoch,Ivana Malíková,Miroslav Zeman,Aleš Linhart +9 more
TL;DR: The abrupt increase in IL-6 immediately after the procedure suggests its involvement in the early stages of the postoperative inflammatory reaction after hip surgery, which is particularly pronounced in elderly patients receiving HA.
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Multimodality imaging in Fabry cardiomyopathy: from early diagnosis to therapeutic targets.
Sebastian Militaru,Carmen Ginghina,Bogdan A. Popescu,Adrian Saftoiu,Aleš Linhart,Ruxandra Jurcut +5 more
TL;DR: The present review summarizes the imaging 'red flags' demonstrated to be able to differentiate early cardiac FD from normal controls and Fabry cardiomyopathy from other causes of hypertrophic cardiopathy and discusses the current evidence for the role of CMR in myocardial tissue characterization, as well as other imaging methods that have shown promise in FD.
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Positive influence of being overweight/obese on long term survival in patients hospitalised due to acute heart failure
Simona Littnerová,Jiri Parenica,Jindrich Spinar,Jiri Vitovec,Aleš Linhart,Petr Widimsky,Jiri Jarkovsky,Roman Miklík,Lenka Špinarová,Kamil Zeman,Jan Belohlavek,Filip Málek,Marian Felsoci,Jiri Kettner,Petr Ostadal,Cestmir Cihalik,Jiri Spac,Hikmet Al-Hiti,Marián Fedorco,Richard Fojt,Andreas Krüger,Josef Malek,Tereza Mikušová,Zdenek Monhart,Stanislava Bohacova,Lidka Pohludkova,Filip Rohac,Jan Václavík,Dagmar Vondrakova,Klaudia Vyskocilova,Miroslav Bambuch,Ladislav Dušek +31 more
TL;DR: It is suggested that at present there is no evidence for weight reduction in overweight/obese patients with heart failure, and the importance of prevention of cardiac cachexia is emphasized.
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Early diastolic mitral annular velocity and color M-mode flow propagation velocity in the evaluation of left ventricular diastolic function in patients with Fabry disease.
Tomáš Paleček,Aleš Linhart,Lubanda Jc,Sudheera Magage,Debora Karetová,Jan Bultas,Michael Aschermann +6 more
TL;DR: Em appears to be superior to Vp in the assessment of LV diastolic function in patients with Fabry disease, and Vp fails to detect abnormal LV diastsolicfunction in subjects with pronounced concentric LV remodeling and pseudonormal filling pattern.