A
Aleš Linhart
Researcher at First Faculty of Medicine, Charles University in Prague
Publications - 371
Citations - 36568
Aleš Linhart is an academic researcher from First Faculty of Medicine, Charles University in Prague. The author has contributed to research in topics: Fabry disease & Medicine. The author has an hindex of 50, co-authored 333 publications receiving 30467 citations. Previous affiliations of Aleš Linhart include University Hospital of Wales & Charles University in Prague.
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Journal ArticleDOI
Microcirculatory blood flow during cardiac arrest and cardiopulmonary resuscitation does not correlate with global hemodynamics: an experimental study
Petra Krupičková,Mikulas Mlcek,Michal Huptych,Zuzana Mormanová,Tomáš Bouček,Tomáš Belza,Stanislav Lacko,Miloš Černý,P Neužil,Otomar Kittnar,Aleš Linhart,Jan Bělohlávek +11 more
TL;DR: Sublingual microcirculatory parameters did not correlate with global hemodynamic parameters during simulated porcine model of CA and CPR and a comparison to parameters of global hemodynamics was provided.
Journal ArticleDOI
Effects of Baseline Left Ventricular Hypertrophy and Decreased Renal Function on Cardiovascular and Renal Outcomes in Patients with Fabry Disease Treated with Agalsidase Alfa: A Fabry Outcome Survey Study.
Sandro Feriozzi,Aleš Linhart,Uma Ramaswami,Vasiliki Kalampoki,Andrey Gurevich,Derralynn Hughes +5 more
TL;DR: The presence of LVH and/or reduced renal function at agalsidase alfa initiation was associated with a significantly higher risk for a cardiovascular or renal event, indicating that cardiovascular and renal pathologies in Fabry disease may be inter-related.
Journal ArticleDOI
Hyperuricemia treatment in acute heart failure patients does not improve their long-term prognosis: A propensity score matched analysis from the AHEAD registry
Marie Pavlušová,Jiri Jarkovsky,Klára Benešová,Jiri Vitovec,Aleš Linhart,Petr Widimsky,Lenka Špinarová,Kamil Zeman,Jan Belohlavek,Filip Málek,Marian Felsoci,Jiri Kettner,Petr Ostadal,Cestmir Cihalik,Jiri Spac,Hikmet Al-Hiti,Marián Fedorco,Richard Fojt,Andreas Krüger,Josef Malek,Tereza Mikušová,Zdenek Monhart,Stanislava Bohacova,Lidka Pohludkova,Filip Rohac,Jan Václavík,Dagmar Vondrakova,Klaudia Vyskocilova,Miroslav Bambuch,Gabriela Dostálová,Stepan Havranek,Ivana Svobodová,Ladislav Dušek,Jindrich Spinar,Roman Miklík,Jiri Parenica +35 more
TL;DR: Assessment of the benefit of allopurinol treatment in a large cohort of heart failure patients found it to be safe and effective to treat hyperuricemia.
Journal ArticleDOI
Arterial stiffening contributes to impairment of cerebrovascular reactivity in patients with coronary artery disease without carotid stenosis.
Rucka D,Josef Marek,Zuzana Rucklova,Lubanda Jc,Stepan Havranek,Jan Skvaril,Varejka P,Miroslav Chochola,Debora Karetová,J Korinek,Aleš Linhart +10 more
TL;DR: Impaired CVR was associated with increased arterial stiffening in CHD patients in the absence of significant carotid stenosis, and it is speculated thatIncreased arterial stiffness may at least partially contribute to the pathophysiology of CVR alteration in coronary artery disease.
Journal ArticleDOI
Fabry disease - Vascular manifestations.
Debora Karetová,Jan Bultas,Gabriela Dostálová,T. Palecek,Tomas Kovarnik,L. Golan,Aleš Linhart +6 more
TL;DR: The majority of FD complications are non-specific (left ventricular hypertrophy, conduction abnormalities, vascular spasms, proteinuria, renal insufficiency), which is why FD still remains largely under diagnosed.