A
Aleš Linhart
Researcher at First Faculty of Medicine, Charles University in Prague
Publications - 371
Citations - 36568
Aleš Linhart is an academic researcher from First Faculty of Medicine, Charles University in Prague. The author has contributed to research in topics: Fabry disease & Medicine. The author has an hindex of 50, co-authored 333 publications receiving 30467 citations. Previous affiliations of Aleš Linhart include University Hospital of Wales & Charles University in Prague.
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Journal ArticleDOI
Enzyme replacement therapy with agalsidase alfa in patients with Fabry's disease: an analysis of registry data
Atul Mehta,Mathias Beck,Perry M. Elliott,Roberto Giugliani,Aleš Linhart,Gere Sunder-Plassmann,Raphael Schiffmann,Frédéric Barbey,Markus Ries,Jtr Clarke,Jtr Clarke +10 more
TL;DR: By comparison with historical natural history data for patients with Fabry's disease who were not treated with enzyme replacement therapy, long-term treatment with agalsidase alfa leads to substantial and sustained clinical benefits.
Journal ArticleDOI
New insights in cardiac structural changes in patients with Fabry's disease.
Aleš Linhart,Tomáš Paleček,Jan Bultas,James J. Ferguson,Jana Hrudová,Debora Karetová,Jiří Zeman,Jana Ledvinová,Helena Poupětová,Milan Elleder,Michael Aschermann +10 more
TL;DR: Echocardiographically detectable cardiac involvement is frequent with Fabry's disease, particularly in older subjects, and more pronounced in affected hemizygous men than in heterozygous women andValvular and especially LV structural changes may serve as a useful marker of disease severity.
Journal ArticleDOI
Triage strategy for urgent management of cardiac tamponade: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases.
Arsen D. Ristić,Massimo Imazio,Yehuda Adler,Aristides Anastasakis,Luigi P. Badano,Antonio Brucato,Alida L.P. Caforio,Olivier Dubourg,Perry M. Elliott,Juan R. Gimeno,Tiina Heliö,Karin Klingel,Aleš Linhart,Bernhard Maisch,Bongani M. Mayosi,Jens Mogensen,Jens Mogensen,Yigal M. Pinto,Hubert Seggewiss,Petar M. Seferović,Luigi Tavazzi,Witold Tomkowski,Philippe Charron +22 more
TL;DR: Management of cardiac tamponade can be challenging because of the lack of the validated criteria for the risk stratification that should guide clinicians in the decision-making process, so updated, evidence-based recommendations are provided.
Journal ArticleDOI
Fabry disease: overall effects of agalsidase alfa treatment.
Mathias Beck,Roberta Ricci,Urs Widmer,F Dehout,A. García de Lorenzo,Christoph Kampmann,Aleš Linhart,Gere Sunder-Plassmann,Gunnar Houge,Uma Ramaswami,Andreas Gal,Atul Mehta +11 more
TL;DR: The first analysis of the FOS database on the effects of ERT on renal function, heart size, pain and quality of life is presented.
Journal ArticleDOI
Serial left ventricular adaptations in world-class professional cyclists: Implications for disease screening and follow-up☆
Eric Abergel,Gilles Chatellier,Albert Hagège,Agnes Oblak,Aleš Linhart,Alain Ducardonnet,Joël Ménard +6 more
TL;DR: Serial examinations showed evidence of further LV dilation along with wall thinning, eliminating the diagnosis of HCM in over one-half of these athletes, which might have important implications for screening in athletes.