A
Aleš Linhart
Researcher at First Faculty of Medicine, Charles University in Prague
Publications - 371
Citations - 36568
Aleš Linhart is an academic researcher from First Faculty of Medicine, Charles University in Prague. The author has contributed to research in topics: Fabry disease & Medicine. The author has an hindex of 50, co-authored 333 publications receiving 30467 citations. Previous affiliations of Aleš Linhart include University Hospital of Wales & Charles University in Prague.
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Journal ArticleDOI
Standardising clinical outcomes measures for adult clinical trials in Fabry disease: A global Delphi consensus.
David Moreno-Martinez,Patricio Aguiar,Christiane Auray-Blais,Mathias Beck,Daniel G. Bichet,Alessandro P. Burlina,Duncan Cole,Perry M. Elliott,Ulla Feldt-Rasmussen,Sandro Feriozzi,Joan Fletcher,R. Giugliani,Ana Jovanovic,Christoph Kampmann,Mirjam Langeveld,Olivier Lidove,Aleš Linhart,Michael Mauer,James C. Moon,Alison Muir,Albina Nowak,João Paulo Oliveira,Alberto Ortiz,Guillem Pintos-Morell,Juan Politei,Paula Rozenfeld,Raphael Schiffmann,Einar Svarstad,Andrew Talbot,Mark Thomas,Camilla Tøndel,David G. Warnock,Michael West,Derralynn Hughes +33 more
TL;DR: A consensus was reached regarding clinical trial design, best treatment comparator, clinical outcomes, measurement of those clinical outcomes and inclusion and exclusion criteria that will help to shape the future of clinical trials in FD.
Journal ArticleDOI
Heart failure in Fabry disease revisited: application of current heart failure guidelines and recommendations
TL;DR: Echocardiographic criteria proposed by current ESC HF guidelines apply to Fabry patients and predict cardiovascular events and were significantly correlated with natriuretic peptides levels.
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The effect of renal denervation in an experimental model of chronic renal insufficiency, The REmnant kidney Denervation In Pigs study (REDIP study)
Lubanda Jc,Miroslav Chochola,Mikulas Mlcek,Petr Neužil,Josef Marek,Štěpán Havránek,Sylvie Kuchynková,Zdeňka Fingrová,Kao-Hsuan Aimee Huang,Aleš Linhart +9 more
TL;DR: This study was not able to show significant protective effect of RDN alone on ischemic renal parenchymal damage by either laboratory or histological assessments, so it is hypothesized that a combined blockade of the RAAS and the sympathetic system could provide more protective effects against acute ischemia.
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Effect of Pulsatility on Microcirculation in Patients Treated with Extracorporeal Cardiopulmonary Resuscitation: A Pilot Study.
Petra Krupičková,Michal Huptych,Zuzana Mormanová,Tomáš Bouček,Tomáš Belza,Ondřej Šmíd,Ales Kral,Hana Skalická,Aleš Linhart,Jan Bělohlávek +9 more
TL;DR: Comparing sublingual microcirculation in patients with refractory cardiac arrest with spontaneously pulsatile or low/nonpulsatile blood flow after treatment with ECPR found only nonsignificant contribution of spontaneous pulsatility to extracorporeal membrane oxygenation-generated microcirculatory blood flow.
Journal Article
The prediction of coronary artery disease based on non-invasive examinations and heme oxygenase 1 polymorphism versus virtual histology.
Tomas Kovarnik,Ales Kral,Hana Skalická,Gary S. Mintz,Králík L,Martin Chvál,Jan Horák,Skalická L,Milan Sonka,Andreas Wahle,Richard W. Downe,Jana Uhrova,Hana Benakova,Lenka Cernohousova,Pavel Martásek,Jan Belohlavek,Michael Aschermann,Aleš Linhart +17 more
TL;DR: Carotid ultrasound and HO-1 polymorphism improve coronary atherosclerosis prediction and predicted plaque burden in patients with stable angina based on non-invasive examinations.