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Alesia Walker
Researcher at Technische Universität München
Publications - 31
Citations - 2047
Alesia Walker is an academic researcher from Technische Universität München. The author has contributed to research in topics: Gut flora & Metabolome. The author has an hindex of 15, co-authored 30 publications receiving 1428 citations.
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Journal ArticleDOI
High-fat diet alters gut microbiota physiology in mice
Hannelore Daniel,Amin Moghaddas Gholami,David Berry,Charles Desmarchelier,Hannes Hahne,Gunnar Loh,Stanislas Mondot,Patricia Lepage,Michael Rothballer,Alesia Walker,Christoph Böhm,Mareike Wenning,Michael Wagner,Michael Blaut,Philippe Schmitt-Kopplin,Bernhard Kuster,Dirk Haller,Thomas Clavel +17 more
TL;DR: It is concluded that a HF diet markedly affects the gut bacterial ecosystem at the functional level.
Journal ArticleDOI
Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD
Thomas Lee,Thomas Clavel,Kirill S. Smirnov,Annemarie Schmidt,Ilias Lagkouvardos,Alesia Walker,Marianna Lucio,Bernhard Michalke,Philippe Schmitt-Kopplin,Richard N. Fedorak,Dirk Haller +10 more
TL;DR: Shifts in gut bacterial diversity and composition associated with iron treatment are pronounced in IBD participants, despite similar clinical outcome, oral administration differentially affects bacterial phylotypes and faecal metabolites compared with IV therapy.
Journal ArticleDOI
The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4+ T Cells.
Meike Kespohl,Niyati Vachharajani,Maik Luu,Hani Harb,Sabine Pautz,Svenja Wolff,Nina Sillner,Alesia Walker,Philippe Schmitt-Kopplin,Thomas Boettger,Harald Renz,Stefan Offermanns,Ulrich Steinhoff,Alexander Visekruna +13 more
TL;DR: The data reveal that, depending on its concentration and immunological milieu, butyrate may exert either beneficial or detrimental effects on the mucosal immune system.
Journal ArticleDOI
Metabolic Functions of Gut Microbes Associate With Efficacy of Tumor Necrosis Factor Antagonists in Patients With Inflammatory Bowel Diseases
Konrad Aden,Ateequr Rehman,Silvio Waschina,Wei-Hung Pan,Alesia Walker,Marianna Lucio,Alejandro Mena Nunez,Richa Bharti,Johannes Zimmerman,Johannes Bethge,Berenice Schulte,Dominik M. Schulte,Andre Franke,Susanna Nikolaus,Johann O. Schroeder,Doris Vandeputte,Jeroen Raes,Silke Szymczak,Georg H. Waetzig,R Zeuner,Philippe Schmitt-Kopplin,Christoph Kaleta,Stefan Schreiber,Philip Rosenstiel +23 more
TL;DR: Metabolic network reconstruction and assessment of metabolic profiles of fecal samples might be used to identify patients with IBD likely to achieve clinical remission following anti-TNF therapy and increase the understanding of the heterogeneity of IBD.
Journal ArticleDOI
Dietary fat and gut microbiota interactions determine diet-induced obesity in mice
Raphaela Kübeck,Catalina Bonet-Ripoll,Christina Hoffmann,Alesia Walker,Veronika Maria Müller,Valentina Schüppel,Ilias Lagkouvardos,Birgit Scholz,Karl-Heinz Engel,Hannelore Daniel,Philippe Schmitt-Kopplin,Dirk Haller,Thomas Clavel,Martin Klingenspor +13 more
TL;DR: It is proposed that an interaction of gut microbiota and cholesterol metabolism is essential for fat accretion in normal SPF mice fed cholesterol-rich lard as the main dietary fat source.