Fabrizio Piras

TL;DR: Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes.

TL;DR: Parkinson-associated physiopathological modifications were characterized in six subcortical structures by simultaneously measuring quantitative magnetic resonance parameters sensitive to complementary tissue characteristics, demonstrating that multimodal magnetic resonance imaging of sub cortical grey matter structures is useful for the evaluation of Parkinson's disease and, possibly, of other subcortsical pathologies.

TL;DR: This review summarizes the last decade of work by the ENIGMA Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease, and highlights the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings.

TL;DR: Results support the notion that the brain alterations responsible for OCD are represented at the network level, and that widespread structural abnormalities may contribute to neurobiological vulnerability to OCD.

TL;DR: There is no consensus about which hippocampal subfields become atrophic earliest in the course of Alzheimer's disease (AD), but efforts are being made to find out which subfields are affected first.