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Alex C. Lam
Researcher at University of Cambridge
Publications - 17
Citations - 2683
Alex C. Lam is an academic researcher from University of Cambridge. The author has contributed to research in topics: Single-nucleotide polymorphism & Gene. The author has an hindex of 12, co-authored 17 publications receiving 2605 citations. Previous affiliations of Alex C. Lam include Yonsei University.
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Journal ArticleDOI
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
John A. Todd,Neil Walker,Jason D. Cooper,Deborah J. Smyth,Kate Downes,Vincent Plagnol,Rebecca Bailey,Sergey Nejentsev,Sarah F. Field,Felicity Payne,Christopher E. Lowe,Jeffrey S. Szeszko,Jason P. Hafler,Lauren R. Zeitels,Jennie H M Yang,Adrian Vella,Adrian Vella,Sarah Nutland,Helen Stevens,Helen Schuilenburg,Gillian Coleman,Meeta Maisuria,William Meadows,Luc J. Smink,Barry C. Healy,Oliver S. Burren,Alex C. Lam,Nigel R. Ovington,James E. Allen,Ellen C. Adlem,H. T. Leung,Chris Wallace,Joanna M. M. Howson,Cristian Guja,Constantin Ionescu-Tirgoviste,Matthew J. Simmonds,Joanne M. Heward,Stephen C. L. Gough,David B. Dunger,Linda S. Wicker,David Clayton +40 more
TL;DR: This study increases the number of T1D loci with compelling evidence from six to at least ten, with evidence for chromosome 18q22 and 18p11, which showed association with autoimmune thyroid disease.
Journal ArticleDOI
Population structure, differential bias and genomic control in a large-scale, case-control association study.
David Clayton,Neil Walker,Deborah J. Smyth,Rebecca Pask,Jason D. Cooper,Lisa M. Maier,Luc J. Smink,Alex C. Lam,Nigel R. Ovington,Helen Stevens,Sarah Nutland,Joanna M. M. Howson,Malek Faham,Martin Moorhead,Hywel B. Jones,Matthew Falkowski,Paul Hardenbol,Thomas D. Willis,John A. Todd +18 more
TL;DR: To avoid excluding SNPs and losing valuable information, the genomic control method is extended by applying a variable downweighting to each SNP, which explains part of the significant +11.2% inflation of test statistics the authors observed in an analysis of 6,322 nonsynonymous SNPs.
Journal ArticleDOI
Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene
Sergey Nejentsev,Lisa Godfrey,Hywel Snook,Helene Rance,Sarah Nutland,Neil Walker,Alex C. Lam,Christian Guja,Constantin Ionescu-Tirgoviste,Dag E. Undlien,Kjersti S. Rønningen,Eva Tuomilehto-Wolf,Jaakko Tuomilehto,Melanie J. Newport,David Clayton,John A. Todd +15 more
TL;DR: Direct comparison indicates that the tag SNPs selected in one European population effectively predict the non-tag SNPs in the other Europeans, but not in the Gambians, for this region.
Journal ArticleDOI
Polymorphic proteins of Chlamydia spp.- autotransporters beyond the Proteobacteria
Ian R. Henderson,Alex C. Lam +1 more
TL;DR: By exploiting the data made available by bacterial genome sequencing, it is discovered that the previously described polymorphic proteins of Chlamydia spp.
Journal ArticleDOI
Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes.
Deborah J Smyth,Joanna M M Howson,Christopher E. Lowe,Neil Walker,Alex C. Lam,Sarah Nutland,Jayne Hutchings,Eva Tuomilehto-Wolf,Jaakko Tuomilehto,Cristian Guja,Constantin Ionescu-Tirgoviste,Dag E. Undlien,Kjersti S. Rønningen,David B. Savage,David B. Dunger,Rebecca C.J. Twells,Wendy L. McArdle,David P. Strachan,John A. Todd +18 more
TL;DR: The results allowed us to assess the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes and investigate the mechanisms leading to this association.