G
Gillian Coleman
Researcher at University of Cambridge
Publications - 7
Citations - 2271
Gillian Coleman is an academic researcher from University of Cambridge. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 7, co-authored 7 publications receiving 2141 citations.
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Journal ArticleDOI
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
John A. Todd,Neil Walker,Jason D. Cooper,Deborah J. Smyth,Kate Downes,Vincent Plagnol,Rebecca Bailey,Sergey Nejentsev,Sarah F. Field,Felicity Payne,Christopher E. Lowe,Jeffrey S. Szeszko,Jason P. Hafler,Lauren R. Zeitels,Jennie H M Yang,Adrian Vella,Adrian Vella,Sarah Nutland,Helen Stevens,Helen Schuilenburg,Gillian Coleman,Meeta Maisuria,William Meadows,Luc J. Smink,Barry C. Healy,Oliver S. Burren,Alex C. Lam,Nigel R. Ovington,James E. Allen,Ellen C. Adlem,H. T. Leung,Chris Wallace,Joanna M. M. Howson,Cristian Guja,Constantin Ionescu-Tirgoviste,Matthew J. Simmonds,Joanne M. Heward,Stephen C. L. Gough,David B. Dunger,Linda S. Wicker,David Clayton +40 more
TL;DR: This study increases the number of T1D loci with compelling evidence from six to at least ten, with evidence for chromosome 18q22 and 18p11, which showed association with autoimmune thyroid disease.
Journal ArticleDOI
Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource
Calliope A. Dendrou,Vincent Plagnol,Erik Fung,Jennie H M Yang,Kate Downes,Jason D. Cooper,Sarah Nutland,Gillian Coleman,Matthew Himsworth,Matthew Hardy,Oliver S. Burren,Barry C. Healy,Neil Walker,Kerstin Koch,Willem H. Ouwehand,Willem H. Ouwehand,John Bradley,Nicholas J. Wareham,John A. Todd,Linda S. Wicker +19 more
TL;DR: Polychromatic flow cytometry is used to show that differences in surface expression of the human interleukin-2 (IL-2) receptor alpha (IL2RA) protein are restricted to particular immune cell types and correlate with several haplotypes in the IL2RA region that have previously been associated with two autoimmune diseases.
Journal ArticleDOI
CD226 Gly307Ser association with multiple autoimmune diseases
Jason P. Hafler,Lisa M. Maier,Jason D. Cooper,Vincent Plagnol,Anne Hinks,Matthew J. Simmonds,Helen Stevens,Neil Walker,Barry C. Healy,Joanna M. M. Howson,M Maisuria,Simon Duley,Gillian Coleman,Stephen C. L. Gough,Jane Worthington,Vijay K. Kuchroo,Linda S. Wicker,John A. Todd +17 more
TL;DR: The Ser307 allele of rs763361 in exon 7 of CD226 predisposes to T1D, MS, and possibly AITD and RA, and based on the tag SNP analysis, could be the causal variant.
Journal ArticleDOI
Seven newly identified loci for autoimmune thyroid disease.
Jason D. Cooper,Matthew J. Simmonds,Neil Walker,Oliver S. Burren,Oliver J. Brand,Hui Guo,Chris Wallace,Helen Stevens,Gillian Coleman,Jayne A. Franklyn,John A. Todd,Stephen C. L. Gough,Stephen C. L. Gough +12 more
TL;DR: An association study using a custom-made single-nucleotide polymorphism (SNP) array, the ImmunoChip, found evidence for seven new AITD risk loci at locations previously associated and two at locations awaiting confirmation, with other immune-mediated diseases.
Journal ArticleDOI
Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial.
John A. Todd,Marina Evangelou,Antony J. Cutler,Marcin L. Pekalski,Neil Walker,Helen Stevens,Linsey Porter,Deborah J. Smyth,Daniel B. Rainbow,Ricardo C. Ferreira,Laura Esposito,Kara Hunter,Kevin W. Loudon,Kathryn Irons,Jennie H M Yang,Charles J.M. Bell,Helen Schuilenburg,James Heywood,Ben Challis,Sankalpa Neupane,Pamela Clarke,Gillian Coleman,Sarah Dawson,Donna Goymer,Katerina Anselmiova,Jane Kennet,Judy Brown,Sarah L Caddy,Jia Lu,Jane Greatorex,Ian Goodfellow,Chris Wallace,Timothy Tree,Mark L. Evans,Adrian Mander,Simon Bond,Simon Bond,Linda S. Wicker,Frank Waldron-Lynch +38 more
TL;DR: A statistical and systematic approach was taken by analysing the pharmacokinetics and pharmacodynamics of single doses of subcutaneous aldesleukin in the Adaptive Study of IL-2 Dose on Regulatory T Cells in Type 1 Diabetes, a single centre, non-randomised, open label, adaptive dose-finding trial with 40 adult participants with recently diagnosed T1D.