J
Jason P. Hafler
Researcher at University of Cambridge
Publications - 6
Citations - 2447
Jason P. Hafler is an academic researcher from University of Cambridge. The author has contributed to research in topics: Single-nucleotide polymorphism & Genome-wide association study. The author has an hindex of 6, co-authored 6 publications receiving 2235 citations.
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Journal ArticleDOI
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
John A. Todd,Neil Walker,Jason D. Cooper,Deborah J. Smyth,Kate Downes,Vincent Plagnol,Rebecca Bailey,Sergey Nejentsev,Sarah F. Field,Felicity Payne,Christopher E. Lowe,Jeffrey S. Szeszko,Jason P. Hafler,Lauren R. Zeitels,Jennie H M Yang,Adrian Vella,Adrian Vella,Sarah Nutland,Helen Stevens,Helen Schuilenburg,Gillian Coleman,Meeta Maisuria,William Meadows,Luc J. Smink,Barry C. Healy,Oliver S. Burren,Alex C. Lam,Nigel R. Ovington,James E. Allen,Ellen C. Adlem,H. T. Leung,Chris Wallace,Joanna M. M. Howson,Cristian Guja,Constantin Ionescu-Tirgoviste,Matthew J. Simmonds,Joanne M. Heward,Stephen C. L. Gough,David B. Dunger,Linda S. Wicker,David Clayton +40 more
TL;DR: This study increases the number of T1D loci with compelling evidence from six to at least ten, with evidence for chromosome 18q22 and 18p11, which showed association with autoimmune thyroid disease.
Journal ArticleDOI
Cutting edge: TIGIT has T cell-intrinsic inhibitory functions.
Nicole Joller,Jason P. Hafler,Boel Brynedal,Boel Brynedal,Nasim Kassam,Silvia Spoerl,Steven D. Levin,Arlene H. Sharpe,Vijay K. Kuchroo +8 more
TL;DR: It is demonstrated that TIGIT can inhibit T cell responses directly independent of APCs by generating an agonistic anti-TIGIT Ab, and can act directly on T cells by attenuating TCR-driven activation signals.
Journal ArticleDOI
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
Vincent Plagnol,Joanna M. M. Howson,Deborah J. Smyth,Neil Walker,Jason P. Hafler,Chris Wallace,Helen Stevens,Laura Jackson,Matthew J. Simmonds,Polly J. Bingley,Stephen C. L. Gough,John A. Todd +11 more
TL;DR: Analysis of the TPOA-associated loci in 2,477 cases with Graves' disease identified two new AITD loci (BACH2 and UBASH3A), and evidence of association with at least one autoantibody at a false discovery rate of 16 was found.
Journal ArticleDOI
CD226 Gly307Ser association with multiple autoimmune diseases
Jason P. Hafler,Lisa M. Maier,Jason D. Cooper,Vincent Plagnol,Anne Hinks,Matthew J. Simmonds,Helen Stevens,Neil Walker,Barry C. Healy,Joanna M. M. Howson,M Maisuria,Simon Duley,Gillian Coleman,Stephen C. L. Gough,Jane Worthington,Vijay K. Kuchroo,Linda S. Wicker,John A. Todd +17 more
TL;DR: The Ser307 allele of rs763361 in exon 7 of CD226 predisposes to T1D, MS, and possibly AITD and RA, and based on the tag SNP analysis, could be the causal variant.
Journal ArticleDOI
Clinical examination for prognostication in comatose cardiac arrest patients.
David M. Greer,David M. Greer,Jingyun Yang,Patricia D. Scripko,John R. Sims,Sydney S. Cash,Ona Wu,Jason P. Hafler,David A. Schoenfeld,Karen L. Furie +9 more
TL;DR: The clinical examination remains central to prognostication in comatose cardiac arrest patients in the modern area, and whether therapeutic hypothermia influences the value of the clinical examination is investigated.