F
Felicity Payne
Researcher at University of Cambridge
Publications - 26
Citations - 4721
Felicity Payne is an academic researcher from University of Cambridge. The author has contributed to research in topics: Single-nucleotide polymorphism & Candidate gene. The author has an hindex of 16, co-authored 24 publications receiving 4535 citations. Previous affiliations of Felicity Payne include Wellcome Trust Sanger Institute & National Institute for Health Research.
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Journal ArticleDOI
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
John A. Todd,Neil Walker,Jason D. Cooper,Deborah J. Smyth,Kate Downes,Vincent Plagnol,Rebecca Bailey,Sergey Nejentsev,Sarah F. Field,Felicity Payne,Christopher E. Lowe,Jeffrey S. Szeszko,Jason P. Hafler,Lauren R. Zeitels,Jennie H M Yang,Adrian Vella,Adrian Vella,Sarah Nutland,Helen Stevens,Helen Schuilenburg,Gillian Coleman,Meeta Maisuria,William Meadows,Luc J. Smink,Barry C. Healy,Oliver S. Burren,Alex C. Lam,Nigel R. Ovington,James E. Allen,Ellen C. Adlem,H. T. Leung,Chris Wallace,Joanna M. M. Howson,Cristian Guja,Constantin Ionescu-Tirgoviste,Matthew J. Simmonds,Joanne M. Heward,Stephen C. L. Gough,David B. Dunger,Linda S. Wicker,David Clayton +40 more
TL;DR: This study increases the number of T1D loci with compelling evidence from six to at least ten, with evidence for chromosome 18q22 and 18p11, which showed association with autoimmune thyroid disease.
Journal ArticleDOI
Haplotype tagging for the identification of common disease genes
Gillian C.L. Johnson,Laura Esposito,Bryan J. Barratt,Annabel N. Smith,Joanne M. Heward,Gianfranco Di Genova,Hironori Ueda,Heather J. Cordell,Iain A. Eaves,Frank Dudbridge,Rebecca C.J. Twells,Felicity Payne,Wil Hughes,Sarah Nutland,Helen Stevens,Phillipa Carr,Eva Tuomilehto-Wolf,Jaakko Tuomilehto,Stephen C. L. Gough,David Clayton,John A. Todd +20 more
TL;DR: This work shows how knowledge of the common haplotypes and the SNPs that tag them can be used to explain the often complex patterns of LD between adjacent markers and provide key fine-mapping data within regions of strong LD.
The UK10K project identifies rare variants in health and disease
Klaudia Walter,Josine L. Min,Jie Huang,Lucy Crooks,Yasin Memari,Shane A. McCarthy,John R. B. Perry,ChangJiang Xu,Marta Futema,Daniel Lawson,Valentina Iotchkova,Stephan Schiffels,Audrey E. Hendricks,Petr Danecek,Rui Li,James A B Floyd,Louise V. Wain,Inês Barroso,Steve E. Humphries,Matthew E. Hurles,Eleftheria Zeggini,Jeffrey C. Barrett,Vincent Plagnol,J. Brent Richards,Celia M. T. Greenwood,Nicholas J. Timpson,Richard Durbin,Nicole Soranzo,Senduran Bala,Peter Clapham,Guy Coates,Tony Cox,Allan Daly,Yuanping Du,Sarah Edkins,Peter R. Ellis,Paul Flicek,Xiaosen Guo,Xueqin Guo,Liren Huang,David K. Jackson,Christopher J. Joyce,Thomas Keane,Anja Kolb-Kokocinski,Cordelia Langford,Yingrui Li,Jieqin Liang,Hong Lin,Ryan Liu,John Maslen,Dawn Muddyman,Michael A. Quail,Jim Stalker,Jianping Sun,Jing Tian,Guangbiao Wang,Jun Wang,Yu Wang,Kim Wong,Pingbo Zhang,Ewan Birney,Chris Boustred,Lu Chen,Gail Clement,Massimiliano Cocca,George Davey Smith,Ian N.M. Day,Aaron G. Day-Williams,Thomas A. Down,Ian Dunham,David M. Evans,Tom R. Gaunt,Matthias Geihs,Deborah J. Hart,Bryan Howie,Tim Hubbard,Pirro G. Hysi,Yalda Jamshidi,Konrad J. Karczewski,John P. Kemp,Genevieve Lachance,Monkol Lek,Margarida C. Lopes,Daniel G. MacArthur,Jonathan Marchini,Massimo Mangino,Iain Mathieson,Sarah Metrustry,Alireza Moayyeri,Kate Northstone,Kalliope Panoutsopoulou,Lavinia Paternoster,Lydia Quaye,Susan M. Ring,Graham R. S. Ritchie,Hashem A. Shihab,So-Youn Shin,Kerrin S. Small,María Soler Artigas,Lorraine Southam,Tim D. Spector,Beate St Pourcain,Gabriela L. Surdulescu,Ioanna Tachmazidou,Martin D. Tobin,Ana M. Valdes,Peter M. Visscher,Kirsten J. Ward,Scott Wilson,Jian Yang,Feng Zhang,Hou-Feng Zheng,Richard Anney,Muhammad Ayub,Douglas Blackwood,Patrick Bolton,Gerome Breen,David A. Collier,Nicholas John Craddock,Sarah Curran,David Curtis,Louise Gallagher,Daniel H. Geschwind,Hugh Gurling,Peter Holmans,Irene Lee,Jouko Lönnqvist,Peter McGuffin,Andrew M. McIntosh,Andrew McKechanie,Andrew McQuillin,James Morris,Michael Conlon O'Donovan,Michael John Owen,Aarno Palotie,Jeremy R. Parr,Tiina Paunio,Olli Pietiläinen,Karola Rehnström,Sally I. Sharp,David Skuse,David St Clair,Jaana Suvisaari,James T.R. Walters,Hywel Williams,Elena G. Bochukova,Rebecca Bounds,Anna F. Dominiczak,I. Sadaf Farooqi,Julia M. Keogh,Gaëlle Marenne,Andrew D. Morris,Stephen O'Rahilly,David J. Porteous,Blair H. Smith,Eleanor Wheeler,Saeed Al Turki,Carl A. Anderson,Dinu Antony,PL Beales,Jamie Bentham,Shoumo Bhattacharya,Mattia Calissano,Keren J. Carss,Krishna Chatterjee,Sebahattin Cirak,Catherine Cosgrove,David R. FitzPatrick,A. Reghan Foley,Christopher S. Franklin,Detelina Grozeva,Hannah M. Mitchison,Francesco Muntoni,Alexandros Onoufriadis,Victoria E. R. Parker,Felicity Payne,F. Lucy Raymond,Nicola D. Roberts,David B. Savage,Peter J. Scambler,Miriam Schmidts,Nadia Schoenmakers,Robert K. Semple,Eva Goncalves Serra,Olivera Spasic-Boskovic,Elizabeth Stevens,Margriet van Kogelenberg,Parthiban Vijayarangakannan,Kathleen A. Williamson,Crispian Wilson,Tamieka Whyte,Antonio Ciampi,Karim Oualkacha,Martin Bobrow,Heather Griffin,Jane Kaye,Karen Kennedy,Alastair Kent,Carol Smee,R. Charlton,Rosemary Ekong,Farrah Khawaja,Luis R. Lopes,Nicola Migone,Stewart J. Payne,Rebecca C. Pollitt,Sue Povey,Cheryl K. Ridout,Rachel L. Robinson,Richard H Scott,Adam Shaw,Petros Syrris,Rohan Taylor,Anthony M. Vandersteen,Antoinette Amuzu,Juan P. Casas,John C. Chambers,George Dedoussis,Giovanni Gambaro,Paolo Gasparini,Aaron Isaacs,Jon Johnson,Marcus E. Kleber,Jaspal S. Kooner,Claudia Langenberg,Jian'an Luan,Giovanni Malerba,Winfried Maerz,Angela Matchan,Richard W Morris,Børge G. Nordestgaard,Marianne Benn,Robert A. Scott,Daniela Toniolo,Michela Traglia,Anne Tybjærg-Hansen,Cornelia M. van Duijn,Elisabeth M. van Leeuwen,Anette Varbo,Peter H. Whincup,Gianluigi Zaza,Weihua Zhang +241 more
TL;DR: The contribution of rare and low-frequency variants to human traits is largely unexplored as mentioned in this paper, but the contribution of these variants to the human traits has not yet been fully explored.
Journal ArticleDOI
Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA
Marjorie J. Lindhurst,Victoria E. R. Parker,Felicity Payne,Julie C. Sapp,Simon A. Rudge,Julie Harris,Alison M. Witkowski,Qifeng Zhang,Matthijs P. Groeneveld,Carol Scott,Allan Daly,Susan M. Huson,Laura L. Tosi,Michael L. Cunningham,Thomas N. Darling,Joseph Geer,Zoran Gucev,V. Reid Sutton,Christos Tziotzios,Adrian K. Dixon,Timothy R. Helliwell,Stephen O'Rahilly,Stephen O'Rahilly,David B. Savage,David B. Savage,Michael J.O. Wakelam,Inês Barroso,Inês Barroso,Leslie G. Biesecker,Robert K. Semple,Robert K. Semple +30 more
TL;DR: The findings characterize a distinct overgrowth syndrome, biochemically demonstrate activation of PI3K signaling and thereby identify a rational therapeutic target.
Journal ArticleDOI
An Activating Mutation of AKT2 and Human Hypoglycemia
Khalid Hussain,Benjamin G. Challis,N. Rocha,Felicity Payne,M. Minic,A. J. Thompson,Allan Daly,Carol Scott,Julie Harris,B. J. L. Smillie,David B. Savage,Uma Ramaswami,P. de Lonlay,Stephen O'Rahilly,Inês Barroso,Inês Barroso,Robert K. Semple +16 more
TL;DR: A key kinase in the insulin signaling pathway is constitutively activated in humans with a severe form of hypoglycemia, and systemic metabolic disease can result from constitutive, cell-autonomous activation of signaling pathways normally controlled by insulin.