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Alexander E. S. Van Driessche
Researcher at University of Savoy
Publications - 72
Citations - 1771
Alexander E. S. Van Driessche is an academic researcher from University of Savoy. The author has contributed to research in topics: Nucleation & Chemistry. The author has an hindex of 19, co-authored 53 publications receiving 1298 citations. Previous affiliations of Alexander E. S. Van Driessche include Tohoku University & Spanish National Research Council.
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Journal ArticleDOI
Role of clusters in nonclassical nucleation and growth of protein crystals
TL;DR: Experimental evidence shows that intermediate metastable states can be liquid-like clusters that are stable with respect to the parent liquid and metastable compared with the emerging crystalline phase and that clusters existing in protein solutions can significantly increase the nucleation rate and therefore play a relevant role in theucleation process.
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Molecular nucleation mechanisms and control strategies for crystal polymorph selection.
Alexander E. S. Van Driessche,Nani Van Gerven,Paul H. H. Bomans,Rick R. M. Joosten,Heiner Friedrich,David Gil-Carton,Nico A. J. M. Sommerdijk,Mike Sleutel +7 more
TL;DR: It is shown that polymorph selection takes place at the earliest stages of structure formation and is based on specific building blocks for each space group, and ways of controlling macromolecular phase transitions are suggested, aiding the development of protein-based drug-delivery systems and macromolescular crystallography.
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Two types of amorphous protein particles facilitate crystal nucleation
Tomoya Yamazaki,Tomoya Yamazaki,Yuki Kimura,Peter G. Vekilov,Erika Furukawa,Manabu Shirai,Hiroaki Matsumoto,Alexander E. S. Van Driessche,Katsuo Tsukamoto +8 more
TL;DR: It is demonstrated that a crystal appears within a noncrystalline particle assembling lysozyme on an ASP or a container wall, highlighting the role of heterogeneous nucleation.
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Formation of calcium sulfate through the aggregation of sub-3 nanometre primary species
Tomasz M. Stawski,Tomasz M. Stawski,Alexander E. S. Van Driessche,Alexander E. S. Van Driessche,M. Ossorio,Juan Diego Rodriguez-Blanco,Rogier Besselink,Liane G. Benning,Liane G. Benning +8 more
TL;DR: Using truly in situ and fast time-resolved small-angle X-ray scattering, this work quantifies the four-stage solution-based nucleation and growth of gypsum (CaSO4·2H2O), an important mineral phase on Earth and Mars, and allows for a quantitative understanding of how natural calcium sulfate deposits may form on Earth.
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Observing classical nucleation theory at work by monitoring phase transitions with molecular precision
Mike Sleutel,James F. Lutsko,Alexander E. S. Van Driessche,Miguel A. Durán-Olivencia,Dominique Maes +4 more
TL;DR: The data show that despite having all the characteristics typically associated with rich phase behaviour, glucose isomerase 2D crystals are formed classically, illustrating the resurfacing importance of the classical nucleation theory by re-validating some of the key assumptions that have been recently questioned.