A
Alexander J. Blake
Researcher at University of Nottingham
Publications - 1136
Citations - 37892
Alexander J. Blake is an academic researcher from University of Nottingham. The author has contributed to research in topics: Crystal structure & Ligand. The author has an hindex of 89, co-authored 1133 publications receiving 35746 citations. Previous affiliations of Alexander J. Blake include University of Illinois at Chicago & University of Wisconsin-Madison.
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Cascade radical cyclisations leading to steroid ring constructions. Regio- and stereo-chemical studies using ester- and fluoro-alkene substituted polyene acyl radical intermediates
Haydn M. Boehm,Sandeep Handa,Gerald Pattenden,Lee R. Roberts,Alexander J. Blake,Wan-Sheung Li +5 more
TL;DR: In this paper, a study of the factors affecting the regio- and stereo-selective outcomes of consecutive 6-endo-trig cyclisations of polyene acyl-radical intermediates, leading to decalone, perhydrophenanthrone, and steroid ring constructions, has been carried out.
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Thioether macrocycles as spacers for crystal engineering: synthesis and crystal structures of [Ag2([24]aneS8)(CF3SO3)2(MeCN)2]∞ and [Ag([16]aneS4)(BF4)]∞([24]aneS8 = 1,4,7,10,13,16,19,22-octathiacyclotetracosane; [16]aneS4 = 1,5,9,13-tetrathiacyclohexadecane)
TL;DR: The polymeric complexes [Ag2([24]aneS8)(CF3SO3)2- (MeCN)2]∞ and [Ag([16]-aneS4)(BF4)]∞ show infinite ladder and layered structures respectively, with the thioether crown controlling the multi-dimensional architecture as mentioned in this paper.
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A microfluidic brain slice perfusion chamber for multisite recording using penetrating electrodes
Alexander J. Blake,Frank C. Rodgers,Anna Bassuener,Joseph A. Hippensteel,Thomas M. Pearce,Timothy R. Pearce,Ewa D. Zarnowska,Robert A. Pearce,Justin C. Williams +8 more
TL;DR: A novel brain slice recording chamber design that provides a stable microfluidic perfusion environment in which tissue health is optimized by superfusing both surfaces of the slice and measuring current sources and sinks during theta burst stimuli that lead to the induction of long-term potentiation in hippocampal slices is presented.
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The asymmetric synthesis of phosphorus- and sulfur-containing tricarbonyl(η6-arene)chromium complexes using the chiral base approach
TL;DR: The use of a simple chiral lithium amide base 2 enables the asymmetric transformation of tricarbonyl[η6-(diphenylphosphinoyl)benzene]chromium(0) 12 into the corresponding ortho-silylated complex in up to 86% ee.
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Iron(II)‐Catalyzed Hydrophosphination of Isocyanates
TL;DR: The use of low-coordinate iron(II) precatalysts leads to an unprecedented catalytic double insertion of isocyanates into the P-H bond of diphenylphosphine to yield phosphinodicarboxamides, a new family of derivatized organophosphorus compounds.