A
Alexander P. Boardman
Researcher at Harvard University
Publications - 6
Citations - 406
Alexander P. Boardman is an academic researcher from Harvard University. The author has contributed to research in topics: Internal medicine & DNA repair. The author has an hindex of 3, co-authored 3 publications receiving 298 citations. Previous affiliations of Alexander P. Boardman include Brigham and Women's Hospital.
Papers
More filters
Journal ArticleDOI
Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response.
Andrew E. H. Elia,Alexander P. Boardman,Alexander P. Boardman,David C. Wang,David C. Wang,Edward L. Huttlin,Robert A. Everley,Noah Dephoure,Chunshui Zhou,Itay Koren,Steven P. Gygi,Stephen J. Elledge +11 more
TL;DR: This work finds that K6- and K33-linked polyubiquitination undergo bulk increases in response to DNA damage, raising the possibility that these linkages are largely dedicated to DDR function, and shows that Cullin-RING ligases mediate 10% of DNA damage-induced ubiquitination events.
Journal ArticleDOI
RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks
Andrew E. H. Elia,David C. Wang,David C. Wang,Nicholas A. Willis,Alexander P. Boardman,Alexander P. Boardman,Ildiko Hajdu,Richard O. Adeyemi,Elizabeth Lowry,Elizabeth Lowry,Steven P. Gygi,Ralph Scully,Stephen J. Elledge +12 more
TL;DR: It is demonstrated that RPA, which functions as a protein scaffold in the replication stress response, is multiply ubiquitinated upon replication fork stalling, and mutations suggest that multisite ubiquitination of the entire RPA complex is responsible for repair at stalled forks.
Journal ArticleDOI
A multicenter phase 1 study of nivolumab for relapsed hematologic malignancies after allogeneic transplantation.
Matthew S. Davids,Haesook T. Kim,Caitlin Costello,Alex F. Herrera,Frederick L. Locke,Rodrigo O. Maegawa,Alexandra Savell,Michael Mazzeo,Adrienne Anderson,Alexander P. Boardman,Augustine Weber,David Avigan,Yi Bin Chen,Sarah Nikiforow,Vincent T. Ho,Corey Cutler,Edwin P. Alyea,Pavan Bachireddy,Catherine J. Wu,Jerome Ritz,Howard Streicher,Edward D. Ball,Asad Bashey,Robert J. Soiffer,Philippe Armand +24 more
TL;DR: In this first prospective clinical trial of an anti-PD-1 antibody for post-alloHCT relapse, GVHD and irAEs occurred, requiring dose de-escalation, with only modest anti-tumor activity.
Journal ArticleDOI
CAR T‐cell therapy in large B cell lymphoma
TL;DR: A detailed overview on clinical data supporting the use of CAR T-cells in patients with large B cell lymphoma (LBCL) can be found in this paper , where the authors provide a detailed overview of clinical data.
Journal ArticleDOI
Predictors and Implications of Renal Injury in Large Cell Lymphoma Patients Receiving CD19 CAR T Cell Therapy
Alexander P. Boardman,Victoria Gutgarts,Jessica Flynn,Sean M. Devlin,Ana Alarcon Tomas,Joshua A Fein,John B. Slingerland,Allison Parascondola,Richard J. Lin,Michael Scordo,Connie Lee Batlevi,Parastoo B. Dahi,Sergio Giralt,M. Lia Palomba,Gilles Salles,Karthik Nath,Moneeza Walji,Magdalena Corona de Lapuerta,Gunjan L. Shah,Miguel-Angel Perales,Insara Jaffer-Sathick,Roni Shouval +21 more
TL;DR: In this paper , a single-center real-world retrospective study was performed on 200 patients with relapsed or refractory large cell lymphoma (LBCL) treated with CAR T cells.