C
Chunshui Zhou
Researcher at Harbin Medical University
Publications - 14
Citations - 2437
Chunshui Zhou is an academic researcher from Harbin Medical University. The author has contributed to research in topics: DNA repair & DNA damage. The author has an hindex of 10, co-authored 14 publications receiving 2214 citations. Previous affiliations of Chunshui Zhou include Harvard University & Brigham and Women's Hospital.
Papers
More filters
Journal ArticleDOI
A quantitative atlas of mitotic phosphorylation.
Noah Dephoure,Chunshui Zhou,Judit Villén,Sean A. Beausoleil,Corey E. Bakalarski,Stephen J. Elledge,Steven P. Gygi +6 more
TL;DR: Analysis of non-proline site-containing phosphopeptides identified two unique motifs that suggest there are at least two undiscovered mitotic kinases, suggesting that many of the proteins identified may be CDK substrates.
Journal ArticleDOI
Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response.
Andrew E. H. Elia,Alexander P. Boardman,Alexander P. Boardman,David C. Wang,David C. Wang,Edward L. Huttlin,Robert A. Everley,Noah Dephoure,Chunshui Zhou,Itay Koren,Steven P. Gygi,Stephen J. Elledge +11 more
TL;DR: This work finds that K6- and K33-linked polyubiquitination undergo bulk increases in response to DNA damage, raising the possibility that these linkages are largely dedicated to DDR function, and shows that Cullin-RING ligases mediate 10% of DNA damage-induced ubiquitination events.
Journal ArticleDOI
Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase.
Tingting Sun,Nicola Aceto,Kristen L. Meerbrey,Jessica D. Kessler,Chunshui Zhou,I. Migliaccio,Don X. Nguyen,Natalya N. Pavlova,Maria F. Botero,Jian Huang,Ronald J. Bernardi,Earlene M. Schmitt,Guang Hu,Mamie Z. Li,Noah Dephoure,Steven P. Gygi,Mitchell Rao,Chad J. Creighton,Susan G. Hilsenbeck,Chad A. Shaw,Donna M. Muzny,Richard A. Gibbs,Richard A. Gibbs,David A. Wheeler,David A. Wheeler,C. Kent Osborne,Rachel Schiff,Mohamed Bentires-Alj,Stephen J. Elledge,Thomas F. Westbrook +29 more
TL;DR: PTPN12 is identified as a commonly inactivated tumor suppressor in triple-negative breast cancer and a rationale for combinatorially targeting proto-oncogenic tyrosine kinases in TNBC and other cancers based on their profile of tyosine-phosphatase activity is provided.
Journal ArticleDOI
Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action
Laura Kapitzky,Pedro Beltrao,Theresa J. Berens,Nadine C. Gassner,Chunshui Zhou,Arthur Wuster,Arthur Wuster,Julie Wu,M. Madan Babu,Stephen J. Elledge,David P. Toczyski,R. Scott Lokey,Nevan J. Krogan +12 more
TL;DR: A novel small molecule that acts as a DNA damaging agent and demonstrate that its MoA is conserved in human cells is identified and identified.
Journal ArticleDOI
Profiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks.
Chunshui Zhou,Andrew E. H. Elia,Maria L. Naylor,Noah Dephoure,Bryan A. Ballif,Gautam Goel,Qikai Xu,Aylwin Ng,Danny M. Chou,Ramnik J. Xavier,Steven P. Gygi,Stephen J. Elledge +11 more
TL;DR: An unbiased approach to profile DDR-dependent phosphorylation in budding yeast reveals a link between DDR signaling and the metabolic pathways of inositol phosphate and phosphatidyl inositl synthesis, which are required for resistance to DNA damage.