N
Nicholas A. Willis
Researcher at Beth Israel Deaconess Medical Center
Publications - 32
Citations - 6206
Nicholas A. Willis is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Homologous recombination & DNA repair. The author has an hindex of 16, co-authored 30 publications receiving 5272 citations. Previous affiliations of Nicholas A. Willis include Massachusetts Institute of Technology & Harvard University.
Papers
More filters
Journal ArticleDOI
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
Erica L. Jackson,Nicholas A. Willis,Kim L. Mercer,Roderick T. Bronson,Denise Crowley,Raymond Montoya,Tyler Jacks,David A. Tuveson +7 more
TL;DR: It is shown that the use of a recombinant adenovirus expressing Cre recombinase (AdenoCre) to induce K-ras G12D expression in the lungs of mice allows control of the timing and multiplicity of tumor initiation.
Journal ArticleDOI
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome.
Kenneth P. Olive,David A. Tuveson,Zachary C. Ruhe,Bob Yin,Nicholas A. Willis,Roderick T. Bronson,Denise Crowley,Tyler Jacks,Tyler Jacks +8 more
TL;DR: It is demonstrated that point mutant p53 alleles expressed under physiological control have enhanced oncogenic potential beyond the simple loss of p53 function.
Journal ArticleDOI
Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects
David A. Tuveson,Alice T. Shaw,Alice T. Shaw,Alice T. Shaw,Nicholas A. Willis,Daniel P. Silver,Erica L. Jackson,Sandy Chang,Kim L. Mercer,Rebecca Grochow,Hanno Hock,Denise Crowley,Sunil R. Hingorani,Tal Z. Zaks,Catrina King,Michael A. Jacobetz,Lifu Wang,Roderick T. Bronson,Stuart H. Orkin,Stuart H. Orkin,Ronald A. DePinho,Tyler Jacks +21 more
TL;DR: It is demonstrated that the conditional expression of an endogenous K-ras(G12D) allele in murine embryonic fibroblasts causes enhanced proliferation and partial transformation in the absence of further genetic abnormalities.
Journal ArticleDOI
DNA double-strand break repair-pathway choice in somatic mammalian cells.
TL;DR: This Review considers DSB repair-pathway choice in somatic mammalian cells as a series of ‘decision trees’, and explores how defective pathway choice can lead to genomic instability.
Journal ArticleDOI
STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications
David A. Tuveson,Nicholas A. Willis,Tyler Jacks,Tyler Jacks,James D. Griffin,Samuel Singer,Christopher D.M. Fletcher,Jonathan A. Fletcher,George D. Demetri +8 more
TL;DR: Cell-culture-based studies support an important role for c-KIT signaling in GIST and suggest therapeutic potential for STI571 in patients afflicted by this chemoresistant tumor.