Oscar A. MacLean

TL;DR: In this article , the authors demonstrate substantial evasion of neutralization by Omicron BA.1 and BA.2 variants in vitro using sera from individuals vaccinated with ChAdOx1, BNT162b2 and mRNA-1273.529.

TL;DR: In this paper, the authors assess the types of natural selection taking place in Sarbecoviruses in horseshoe bats versus the early SARS-CoV-2 evolution in humans.

TL;DR: It is shown that immunity from natural infection (without vaccination) is more protective than two doses of vaccine but inferior to three doses, and fundamental changes in the Omicron entry process in vitro, towards TMPRSS2-independent fusion, representing a major shift in the replication properties of SARS-CoV-2.

TL;DR: The authors examined patterns of synonymous and non-synonymous mutations accumulated in SARS-CoV-2 genomes since the pandemic began and found that the emergence of these three "501Y lineages" coincided with a major global shift in the selective forces acting on various SARS CoV2 genes.

TL;DR: It is shown that the major conclusions of that paper cannot be substantiated, and the difficulty in demonstrating the existence or nature of a functional effect of a viral mutation is discussed, and overinterpretation of genomic data during the pandemic is advised.