Alexandra L. Brown

TL;DR: It is reported that the metabolic effects of resveratrol result from competitive inhibition of cAMP-degrading phosphodiesterases, leading to elevated cAMP levels, and administration of PDE4 inhibitors may also protect against and ameliorate the symptoms of metabolic diseases associated with aging.

TL;DR: It is reported that the human Cds1 kinase (hCds1/Chk2) regulates BRCA1 function after DNA damage by phosphorylating serine 988 of BRC a1, and it is shown that hCDS1 and BRCa1 interact and co-localize within discrete nuclear foci but separate after gamma irradiation.

TL;DR: Tissue-specific differences in the developmental regulation of the expression of IGF-II RNA exhibit intriguing temporal correlations with major maturational events in some tissues such as lung and muscle.

TL;DR: The identification of a human cDNA encoding a protein that shares sequence, structural, and functional similarity to SpCds1 is reported, suggesting that the checkpoint function of HuCDS1 is conserved in yeast and mammals.

TL;DR: The rat IGF binding protein that is cloned appears to be a distinct member of a family of related IGF binding proteins, and it is postulate that the structurally distinct IGFbinding proteins may have different biological functions.