H
Holger Rehmann
Researcher at Utrecht University
Publications - 81
Citations - 8499
Holger Rehmann is an academic researcher from Utrecht University. The author has contributed to research in topics: Guanine nucleotide exchange factor & Rap1. The author has an hindex of 41, co-authored 78 publications receiving 7578 citations. Previous affiliations of Holger Rehmann include Max Planck Society & University Medical Center Utrecht.
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Journal ArticleDOI
GEFs and GAPs: Critical Elements in the Control of Small G Proteins
TL;DR: GEFs and GAPs are multidomain proteins that are regulated by extracellular signals and localized cues that control cellular events in time and space and are potential therapeutic targets for developing drugs to treat various diseases, including cancer.
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Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases
Sung-Jun Park,Faiyaz Ahmad,Andrew Philp,Keith Baar,Tishan Williams,Haibin Luo,Hengming Ke,Holger Rehmann,Ronald Taussig,Alexandra L. Brown,Myung K. Kim,Michael A. Beaven,Alex B. Burgin,Vincent C. Manganiello,Jay H. Chung +14 more
TL;DR: It is reported that the metabolic effects of resveratrol result from competitive inhibition of cAMP-degrading phosphodiesterases, leading to elevated cAMP levels, and administration of PDE4 inhibitors may also protect against and ameliorate the symptoms of metabolic diseases associated with aging.
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Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling
Stephan Huveneers,Joppe Oldenburg,Emma Spanjaard,Gerard van der Krogt,Ilya Grigoriev,Anna Akhmanova,Holger Rehmann,Johan de Rooij +7 more
TL;DR: A specialized subset of VE-cadherin adhesions senses cytoskeletal force and recruits Vinculin to control the stability of endothelial cell–cell junctions during their force-dependent remodeling.
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Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.
J. de Rooij,Holger Rehmann,Holger Rehmann,M. van Triest,Robbert H. Cool,Alfred Wittinghofer,Johannes L. Bos +6 more
TL;DR: All three members of the Epac family regulate both Rap1 and Rap2, and it is concluded that the catalytic activity of Epac1 is constrained by a direct interaction between GEF and high affinity cAMP binding domains in the absence of cAMP.
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A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase.
Martina Schmidt,Sandrine Evellin,Paschal A. Oude Weernink,Frank vom Dorp,Holger Rehmann,Jon W. Lomasney,Karl Jakobs +6 more
TL;DR: A new PLC and calcium signalling pathway that is triggered by cyclic AMP (cAMP) and mediated by a small GTPase of the Rap family is reported, and involve the recently identified PLC-ɛ isoform.