Developmental regulation of insulin-like growth factor II mRNA in different rat tissues.
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TLDR
Tissue-specific differences in the developmental regulation of the expression of IGF-II RNA exhibit intriguing temporal correlations with major maturational events in some tissues such as lung and muscle.About:
This article is published in Journal of Biological Chemistry.The article was published on 1986-10-05 and is currently open access. It has received 317 citations till now. The article focuses on the topics: RNA & Messenger RNA.read more
Citations
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Journal ArticleDOI
Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations
TL;DR: Current progress in the immunological measurement of the IGF is reviewed including different strategies for avoiding binding protein interference and an attempt is made to indicate circumstances in which the IGFs are exerting their actions in an autocrine/paracrine mode and when endocrine actions predominate.
Journal ArticleDOI
Insulin-like growth factor II receptor as a multifunctional binding protein.
David O. Morgan,David O. Morgan,Jeffrey C. Edman,David Standring,Victor A. Fried,Michele C. Smith,Richard A. Roth,William J. Rutter +7 more
TL;DR: The primary structure of human insulin-like growth factor II receptor, predicted from the complementary DNA sequence, reveals a transmembrane receptor molecule with a large extracellular domain made up of fifteen repeat sequences and a small region homologous to the collagen-binding domain of fibronectin.
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Differential expression of insulin-like growth factor genes in rat central nervous system.
TL;DR: Observations show that IGF-I and IGF-II are differentially expressed in the developing and adult CNS and suggest that each growth factor may play a unique role in the mammalian nervous system.
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Insulin-like growth factor I increases brain growth and central nervous system myelination in tTransgenic mice
TL;DR: It is shown that IGF-I is a potent inducer of brain growth and myelination in vivo and that the brains of transgenic mice were 55% larger than those of controls owing to an increase in cell size and apparently in cell number.
References
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RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination.
TL;DR: RNA molecular weight measurements were carried out by gel electrophoresis under four different denaturing conditions including 99% formamide, 10 mM methyl mercury, 2.2 M formaldehyde, and 6 M urea at pH 3.8 to demonstrate reliable molecular weight determinations of denatured RNAs, especially those obtained by extrapolation.
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Autocrine Secretion and Malignant Transformation of Cells
TL;DR: The growth of normal cells is largely controlled by the interplay between several polypeptide hormones and hormone-like growth factors that are present in tissue fluids.
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A Method for Isolation of Intact, Translationally Active Ribonucleic Acid
Guy Cathala,Jean-François Savouret,Bernardita Mendez,Brian L. West,Michael Karin,Joseph Martial,John D. Baxter +6 more
TL;DR: A method for isolation of large, translationally active RNA species is presented and yields large mRNA precursors up to 10 kb and mRNA species which translate very well, however, small RNA species are recovered with a poor yield.
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Radioimmunological determination of insulinlike growth factors I and II in normal subjects and in patients with growth disorders and extrapancreatic tumor hypoglycemia.
Jürgen Zapf,H Walter,E R Froesch +2 more
TL;DR: Serum levels of immunoreactive insulinlike growth factors (IGF) I and II were determined by a modified IGF I and a new IGF II radioimmunoassay in normal children and adults, and in patients with acromegaly, isolated growth hormone deficiency, and extrapancreatic tumor hypoglycemia.
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Synthesis and Secretion of Insulin-Like Growth Factor and Its Binding Protein by the Perfused Rat Liver: Dependence on Growth Hormone Status*
TL;DR: The data suggest that IGF is continuously synthesized and released by the liver, and suggests that the liver is the major site of IGF production in the rat.