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Alexandre Seyer
Researcher at Institut de Chimie des Substances Naturelles
Publications - 23
Citations - 861
Alexandre Seyer is an academic researcher from Institut de Chimie des Substances Naturelles. The author has contributed to research in topics: Lipid metabolism & Mass spectrometry. The author has an hindex of 15, co-authored 23 publications receiving 705 citations. Previous affiliations of Alexandre Seyer include Centre national de la recherche scientifique.
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Journal ArticleDOI
Impact of rhizosphere factors on cyclic lipopeptide signature from the plant beneficial strain Bacillus amyloliquefaciens S499
TL;DR: Electrospray and imaging mass spectrometry-based approaches were combined to determine the detailed pattern of surfactins, iturins and fengycins produced in planta by Bacillus amyloliquefaciens S499, revealing that lipopeptide production by root-associated S499 cells is qualitatively and quantitatively dictated by the specific nutritional context of the rhizosphere.
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Mass spectrometry imaging of rat brain sections: nanomolar sensitivity with MALDI versus nanometer resolution by TOF–SIMS
Farida Benabdellah,Alexandre Seyer,Loïc Quinton,David Touboul,Alain Brunelle,Olivier Laprévote,Olivier Laprévote +6 more
TL;DR: In this article, the authors compared the similarities, differences, and specificities of ion images generated by matrix-assisted laser desorption/ionizaton and secondary ion mass spectrometry in terms of sample preparation, sensitivity, ultimate spatial resolution and structural analysis.
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Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model
Lodewijk J.A. Toonen,Maurice Overzier,Melvin M. Evers,Leticia G. Leon,Sander A.J. van der Zeeuw,Hailiang Mei,Szymon M. Kielbasa,Jelle J. Goeman,Kristina Hettne,Olafur T. Magnusson,Marion Poirel,Alexandre Seyer,Peter A C 't Hoen,Peter A C 't Hoen,Willeke M. C. van Roon-Mom +14 more
TL;DR: The observed transcriptional changes inSCA3 mouse brain reveal parallels with previous reported neuropathology in patients, but also shows brain region specific effects as well as involvement of adrenergic signalling and CREB pathway changes in SCA3.
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Inhibition of Lysosome Membrane Recycling Causes Accumulation of Gangliosides that Contribute to Neurodegeneration.
Maxime Boutry,Julien Branchu,Céline Lustremant,Claire Pujol,Julie Pernelle,Raphaël Matusiak,Alexandre Seyer,Marion Poirel,Emeline Chu-Van,Alexandre Pierga,Kostantin Dobrenis,Jean Philippe Puech,Catherine Caillaud,Alexandra Durr,Alexis Brice,Benoit Colsch,Fanny Mochel,Khalid Hamid El Hachimi,Giovanni Stevanin,Frédéric Darios +19 more
TL;DR: It is shown that spatacsin, which is required for lysosome recycling and whose loss of function leads to hereditary spastic paraplegia 11 (SPG11), promotes clearance of gangliosides from lysOSomes in mouse and human SPG11 models.
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Lipid mapping of colonic mucosa by cluster TOF-SIMS imaging and multivariate analysis in cftr knockout mice
Marc Brulet,Alexandre Seyer,Aleksander Edelman,Alain Brunelle,Janine Fritsch,Mario Ollero,Mario Ollero,Olivier Laprévote,Olivier Laprévote +8 more
TL;DR: This study shows for the first time the spatial distribution of lipids in colonic mucosa and suggests TOF-SIMS plus multivariate analyses as a powerful tool to investigate disease-related tissue spatial lipid signatures.