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Arkady Celeste
Researcher at National Institutes of Health
Publications - 23
Citations - 8507
Arkady Celeste is an academic researcher from National Institutes of Health. The author has contributed to research in topics: DNA damage & DNA repair. The author has an hindex of 21, co-authored 23 publications receiving 8147 citations.
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Journal ArticleDOI
Genomic instability in mice lacking histone H2AX.
Arkady Celeste,Simone Petersen,Peter J. Romanienko,Oscar Fernandez-Capetillo,Hua Tang Chen,Olga A. Sedelnikova,Bernardo Reina-San-Martin,Vincenzo Coppola,Eric Meffre,Michael J. Difilippantonio,Christophe E. Redon,Duane R. Pilch,Alexandru Olaru,Michael Eckhaus,R. Daniel Camerini-Otero,Lino Tessarollo,Ferenc Livak,Katia Manova,William M. Bonner,Michel C. Nussenzweig,André Nussenzweig +20 more
TL;DR: Higher order chromatin structure presents a barrier to the recognition and repair of DNA damage, and H2AX is critical for facilitating the assembly of specific DNA-repair complexes on damaged DNA.
Journal ArticleDOI
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks
Arkady Celeste,Oscar Fernandez-Capetillo,Michael J. Kruhlak,Duane R. Pilch,David W. Staudt,Alicia Lee,Robert F. Bonner,William M. Bonner,André Nussenzweig +8 more
TL;DR: It is proposed that γ-H2AX does not constitute the primary signal required for the redistribution of repair complexes to damaged chromatin, but may function to concentrate proteins in the vicinity of DNA lesions.
Journal ArticleDOI
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.
Oscar Fernandez-Capetillo,Hua Tang Chen,Arkady Celeste,Irene M. Ward,Peter J. Romanienko,Julio C. Morales,Kazuhito Naka,Zhengfang Xia,R. Daniel Camerini-Otero,Noboru Motoyama,Phillip B. Carpenter,William M. Bonner,Junjie Chen,André Nussenzweig +13 more
TL;DR: It is proposed that at threshold levels of DNA damage, H2AX-mediated concentration of 53BP1 at double-strand breaks is essential for the amplification of signals that might otherwise be insufficient to prevent entry of damaged cells into mitosis.
Journal ArticleDOI
MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals
Zhenkun Lou,Katherine Minter-Dykhouse,Sonia Franco,Monica Gostissa,Melissa A. Rivera,Arkady Celeste,John P. Manis,Jan M. van Deursen,André Nussenzweig,Tanya T. Paull,Frederick W. Alt,Junjie Chen +11 more
TL;DR: It is suggested that MDC1, as a signal amplifier of the ATM pathway, is vital in controlling proper DNA damage response and maintaining genomic stability.
Journal ArticleDOI
H2AX Is Required for Chromatin Remodeling and Inactivation of Sex Chromosomes in Male Mouse Meiosis
Oscar Fernandez-Capetillo,Shantha K. Mahadevaiah,Arkady Celeste,Peter J. Romanienko,R. Daniel Camerini-Otero,William M. Bonner,Katia Manova,Paul S. Burgoyne,André Nussenzweig +8 more
TL;DR: It is shown that the X and Y chromosomes of histone H2AX-deficient spermatocytes fail to condense to form a sex body, do not initiate MSCI, and exhibit severe defects in meiotic pairing.