A
Ali Saad
Researcher at University of Sousse
Publications - 204
Citations - 3748
Ali Saad is an academic researcher from University of Sousse. The author has contributed to research in topics: Fluorescence in situ hybridization & Chromosomal translocation. The author has an hindex of 29, co-authored 173 publications receiving 3027 citations. Previous affiliations of Ali Saad include United Arab Emirates University & University Teaching Hospital.
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Journal ArticleDOI
Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation
Franklin L. Zhong,Ons Mamaï,Lorenzo Sborgi,Lobna Boussofara,Richard Hopkins,Kim S. Robinson,Ildikó Szeverényi,Takuya Takeichi,Takuya Takeichi,Reshmaa Balaji,Aristotle Lau,Hazel Tye,Hazel Tye,Keya Roy,Carine Bonnard,Patricia J. Ahl,L. A. Jones,Paul J. Baker,Paul J. Baker,Lukáš Lacina,Atsushi Otsuka,Pierre Fournié,François Malecaze,E. Birgitte Lane,Masashi Akiyama,Kenji Kabashima,Kenji Kabashima,John E. Connolly,Seth L. Masters,Seth L. Masters,Vincent Soler,Salma Samir Omar,John A. McGrath,Roxana Ioana Nedelcu,Moez Gribaa,Mohamed Denguezli,Ali Saad,Sebastian Hiller,Bruno Reversade +38 more
TL;DR: It is found that germline mutations in the inflammasome sensor NLRP1 cause two overlapping skin disorders: multiple self-healing palmoplantar carcinoma (MSPC) and familial keratosis lichenoides chronica (FKLC) and the first genetic evidence linkingNLRP1 to skin inflammatory syndromes and skin cancer predisposition is provided.
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Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromes
Enza Maria Valente,Clare V. Logan,Soumaya Mougou-Zerelli,Jeong Ho Lee,Jennifer L. Silhavy,Francesco Brancati,Francesco Brancati,Miriam Iannicelli,Lorena Travaglini,Sveva Romani,Barbara Illi,Matthew Adams,Katarzyna Szymanska,Annalisa Mazzotta,Ji Eun Lee,Jerlyn C Tolentino,Dominika Swistun,Carmelo Salpietro,Carmelo Fede,Stacey Gabriel,Carsten Russ,Kristian Cibulskis,Carrie Sougnez,Friedhelm Hildebrandt,Edgar A. Otto,Susanne Held,Bill H. Diplas,Erica E. Davis,Mario Mikula,Charles M. Strom,Bruria Ben-Zeev,Dorit Lev,Tally Lerman Sagie,Marina Michelson,Yuval Yaron,Amanda Krause,Eugen Boltshauser,Nadia Elkhartoufi,Joelle Roume,Stavit A. Shalev,Arnold Munnich,Sophie Saunier,Chris F. Inglehearn,Ali Saad,Adila Al-Kindy,Adila Al-Kindy,Sophie Thomas,Michel Vekemans,Bruno Dallapiccola,Nicholas Katsanis,Colin A. Johnson,Tania Attié-Bitach,Joseph G. Gleeson +52 more
TL;DR: It is reported that MKS2 and CORS2 (JBTS2) loci are allelic and caused by mutations in TMEM216, which encodes an uncharacterized tetraspan transmembrane protein.
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Relationship between sperm aneuploidy, sperm DNA integrity, chromatin packaging, traditional semen parameters, and recurrent pregnancy loss
Ines Zidi-Jrah,Amani Hajlaoui,Soumaya Mougou-Zerelli,Molka Kammoun,Imene Meniaoui,Amira Sallem,Sonia Brahem,Meriem Fekih,Mohammed Bibi,Ali Saad,Samira Ibala-Romdhane +10 more
TL;DR: The increase in abnormal sperm parameters, sperm DNA fragmentation, nuclear chromatin decondensation, and sperm aneuploidy suggest possible causes of unexplained RPL.
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Single autologous stem cell transplantation followed by maintenance therapy with thalidomide is superior to double autologous transplantation in multiple myeloma: results of a multicenter randomized clinical trial
Abderrahman Abdelkefi,Saloua Ladeb,Lamia Torjman,Tarek Ben Othman,Amel Lakhal,Neila Ben Romdhane,Halima El Omri,Moez Elloumi,Hatem Belaaj,Ramzi Jeddi,Lamia Aissaoui,Habib Ksouri,Assia Ben Hassen,Fahmi Msadek,Ali Saad,Mohamed Hsairi,K. Boukef,Ahlem Amouri,Hechmi Louzir,Koussay Dellagi,Abdeladhim Ben Abdeladhim +20 more
TL;DR: Up-front single autologous transplantation followed by 6 months of maintenance therapy with thalidomide is an effective therapeutic strategy to treat multiple myeloma patients and appears superior to tandem transplant in this setting.
Journal ArticleDOI
Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases
TL;DR: Recent preclinical as well as clinical results that support the relevance of H3R antagonists for the treatment of cognitive symptoms in neuropsychiatric diseases, namely AD, epilepsy and SCH are focused on.