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Alicia A. Midland
Researcher at University of North Carolina at Chapel Hill
Publications - Â 3
Citations - Â 807
Alicia A. Midland is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Kinome & Receptor tyrosine kinase. The author has an hindex of 3, co-authored 3 publications receiving 723 citations.
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Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer
James S. Duncan,Martin C. Whittle,Kazuhiro Nakamura,Amy N. Abell,Alicia A. Midland,Jon S. Zawistowski,Nancy Lassignal Johnson,Deborah A. Granger,Nicole Vincent Jordan,David B. Darr,Jerry Usary,Pei Fen Kuan,David M. Smalley,Ben Major,Xiaping He,Katherine A. Hoadley,Bing Zhou,Norman E. Sharpless,Charles M. Perou,William Y. Kim,Shawn M. Gomez,Xin Chen,Jian Jin,Stephen V. Frye,H. Shelton Earp,Lee M. Graves,Gary L. Johnson +26 more
TL;DR: The inhibitor-induced RTK profile suggested a kinase inhibitor combination therapy that produced GEMM tumor apoptosis and regression where single agents were ineffective, allowing rational design of combination therapies for cancer.
Journal ArticleDOI
MAP3K4/CBP-Regulated H2B Acetylation Controls Epithelial-Mesenchymal Transition in Trophoblast Stem Cells
Amy N. Abell,Nicole Vincent Jordan,Weichun Huang,Aleix Prat,Alicia A. Midland,Nancy Lassignal Johnson,Deborah A. Granger,Piotr A. Mieczkowski,Charles M. Perou,Shawn M. Gomez,Leping Li,Gary L. Johnson +11 more
TL;DR: It is shown that MAP3K4 controls the activity of the histone acetyltransferase CBP, and that acetylation of histones H2A and H2B by CBP is required to maintain the epithelial phenotype.
Journal ArticleDOI
Defining the expressed breast cancer kinome.
Alicia A. Midland,Martin C. Whittle,James S. Duncan,Amy N. Abell,Kazuhiro Nakamura,Jon S. Zawistowski,Lisa A. Carey,H. Shelton Earp,Lee M. Graves,Shawn M. Gomez,Gary L. Johnson +10 more
TL;DR: A rich network both downstream and upstream from key oncogenic kinases includes both tyrosine and serine/threonine kinases, giving plasticity and resiliency to the cancer cell kinome.