D
David M. Smalley
Researcher at University of North Carolina at Chapel Hill
Publications - 40
Citations - 3176
David M. Smalley is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Platelet-activating factor & Shock (circulatory). The author has an hindex of 23, co-authored 40 publications receiving 3018 citations. Previous affiliations of David M. Smalley include University of Kansas & University of Virginia.
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Journal ArticleDOI
Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer
James S. Duncan,Martin C. Whittle,Kazuhiro Nakamura,Amy N. Abell,Alicia A. Midland,Jon S. Zawistowski,Nancy Lassignal Johnson,Deborah A. Granger,Nicole Vincent Jordan,David B. Darr,Jerry Usary,Pei Fen Kuan,David M. Smalley,Ben Major,Xiaping He,Katherine A. Hoadley,Bing Zhou,Norman E. Sharpless,Charles M. Perou,William Y. Kim,Shawn M. Gomez,Xin Chen,Jian Jin,Stephen V. Frye,H. Shelton Earp,Lee M. Graves,Gary L. Johnson +26 more
TL;DR: The inhibitor-induced RTK profile suggested a kinase inhibitor combination therapy that produced GEMM tumor apoptosis and regression where single agents were ineffective, allowing rational design of combination therapies for cancer.
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Native Low-Density Lipoprotein Increases Endothelial Cell Nitric Oxide Synthase Generation of Superoxide Anion
Kirkwood A. Pritchard,Laura Groszek,David M. Smalley,William C. Sessa,Mingdan Wu,Patricio Villalon,Michael S. Wolin,Michael B. Stemerman +7 more
TL;DR: In this article, low-density lipoprotein (n-LDL) perturbs endothelial cell (EC) release of superoxide anion (O2-) and nitric oxide (NO), which increases the likelihood of the formation of peroxynitrite (ONOO-), a potent oxidant.
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The platelet microparticle proteome.
Benjamin A. Garcia,David M. Smalley,HyungJun Cho,Jeffrey Shabanowitz,Klaus Ley,Donald F. Hunt +5 more
TL;DR: The first proteomic analysis of microparticles generated from activated platelets using 1D SDS-PAGE and liquid chromatography coupled to a linear ion trap mass spectrometer identified 578 proteins, many of which have been previously implicated in microparticle formation and/or pathological function.
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L-selectin: mechanisms and physiological significance of ectodomain cleavage.
David M. Smalley,Klaus Ley +1 more
TL;DR: The mechanism(s) of L‐selectin ectodomain shedding is examined, the physiological implications are discussed, and gene transcription, post‐translational modifications, association with the actin cytoskeleton, and topographic distribution are discussed.
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Isolation and Identification of Potential Urinary Microparticle Biomarkers of Bladder Cancer
TL;DR: Eight proteins were elevated in the microparticles from individuals with bladder cancer, including five proteins associated with the epidermal growth factor receptor pathway, the alpha subunit of GsGTP binding protein, resistin, and retinoic acid-induced protein 3.