Kazuhiro Nakamura

TL;DR: The inhibitor-induced RTK profile suggested a kinase inhibitor combination therapy that produced GEMM tumor apoptosis and regression where single agents were ineffective, allowing rational design of combination therapies for cancer.

TL;DR: This review presents the current understanding of JNK regulation and their involvement in homeostasis and dysregulation in human disease and describes JNK/SAPK involvement in proliferation, apoptosis, motility, metabolism and DNA repair.

TL;DR: To make the tumor response to single kinase inhibitors durable, the adaptive kinome response itself must be inhibited, and combining inhibitors of kinases and chromatin readers prevents kinome adaptation by blocking transcription, generating a durable response to lapatinib, and overcoming the dilemma of heterogeneity in the adaptive response.

TL;DR: It is demonstrated that the rear end acidic cluster region of the p62 PB1 domain binds the front end basic region ofThe MAPK kinase kinase, MEKK3.

TL;DR: It is proposed that signal transduction network wiring diagrams are valuable tools for hypothesis building and filtering physiologically relevant phenotypic responses from less connected protein relations in the regulation of MAPK pathways.