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Alla Grishok
Researcher at Boston University
Publications - 44
Citations - 6426
Alla Grishok is an academic researcher from Boston University. The author has contributed to research in topics: RNA interference & Caenorhabditis elegans. The author has an hindex of 20, co-authored 42 publications receiving 6165 citations. Previous affiliations of Alla Grishok include Medical College of Wisconsin & Columbia University Medical Center.
Papers
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Journal ArticleDOI
Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
Alla Grishok,Amy E. Pasquinelli,Darryl Conte,Na Li,Susan Parrish,Ilho Ha,David L. Baillie,Andrew Fire,Gary Ruvkun,Craig C. Mello +9 more
TL;DR: It is shown that inactivation of genes related to RNAi pathway genes, a homolog of Drosophila Dicer (dcr-1), and two homologs of rde-1 (alg-1 and alg-2), cause heterochronic phenotypes similar to lin-4 and let-7 mutations.
Journal ArticleDOI
The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans
Hiroaki Tabara,Madathia Sarkissian,William G. Kelly,Jamie Fleenor,Alla Grishok,Lisa Timmons,Andrew Fire,Craig C. Mello +7 more
TL;DR: It is shown that rde-1 is a member of the piwi/sting/argonaute/zwille/eIF2C gene family conserved from plants to vertebrates and the possibility that one natural function of RNAi is transposon silencing is discussed.
Journal ArticleDOI
RNAi in C. elegans: Soaking in the Genome Sequence
TL;DR: The completion of the Caenorhabditis elegans genome sequence represents a major milestone in a journey initiated by Sydney Brenner some 30 years ago to discover how genetic information specifies the development, anatomy, and behavior of a simple animal.
Journal ArticleDOI
Genetic Requirements for Inheritance of RNAi in C. elegans
TL;DR: Findings provide evidence for germ line transmission of an extragenic sequence-specific silencing factor and implicate rde-1 and r de-4 in the formation of the inherited agent.
Patent
Rna interference pathway genes as tools for targeted genetic interference
TL;DR: In this paper, genes involved in double-stranded RNA interference (RNAi pathway genes) are identified and used to investigate the RNAi pathway and their products are also useful for modulating RNA pathway activity.