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Allan Munck
Researcher at Dartmouth College
Publications - 97
Citations - 17668
Allan Munck is an academic researcher from Dartmouth College. The author has contributed to research in topics: Receptor & Glucocorticoid receptor. The author has an hindex of 48, co-authored 97 publications receiving 17030 citations. Previous affiliations of Allan Munck include University of Minnesota.
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How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.
TL;DR: This review considers recent findings regarding GC action and generates criteria for determining whether a particular GC action permits, stimulates, or suppresses an ongoing stress-response or, as an additional category, is preparative for a subsequent stressor.
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Physiological Functions of Glucocorticoids in Stress and Their Relation to Pharmacological Actions
TL;DR: It is proposed that stress-induced increases in glucocorticoid levels protect not against the source of stress itself but rather against the body's normal reactions to stress, preventing those reactions from overshooting and themselves threatening homeostasis.
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T cell growth factor receptors. Quantitation, specificity, and biological relevance
TL;DR: The results indicate that TCGF interacts with activated T cells via a receptor through which it initiates the T cell proliferative response, and the relative magnitude of T cell proliferation induced by a given concentration of TCGF closely paralleled the fraction of occupied receptor sites.
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Specific and Nonspecific Physicochemical Interactions of Glucocorticoids and Related Steroids with Rat Thymus Cells in Vitro
Allan Munck,Truls Brinck-Johnsen +1 more
TL;DR: Binding of glucocorticoids and related steroids to rat thymus cells in vitro has been measured by equilibrium and kinetic methods, adding to the evidence that the hormonally active form of cortisol is cortisol itself.
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Mouse Glucocorticoid Receptor Phosphorylation Status Influences Multiple Functions of the Receptor Protein
Jeffrey C. Webster,Christine M. Jewell,Jack E. Bodwell,Allan Munck,Madhabananda Sar,John A. Cidlowski +5 more
TL;DR: Receptors containing seven or eight mutated sites have a markedly extended half-life and do not show the ligand-dependent destabilization seen with wild type receptor, showing that receptor phosphorylation may play a crucial role in regulating receptor levels and hence control receptor functions.