Mouse Glucocorticoid Receptor Phosphorylation Status Influences Multiple Functions of the Receptor Protein
Jeffrey C. Webster,Christine M. Jewell,Jack E. Bodwell,Allan Munck,Madhabananda Sar,John A. Cidlowski +5 more
Reads0
Chats0
TLDR
Receptors containing seven or eight mutated sites have a markedly extended half-life and do not show the ligand-dependent destabilization seen with wild type receptor, showing that receptor phosphorylation may play a crucial role in regulating receptor levels and hence control receptor functions.About:
This article is published in Journal of Biological Chemistry.The article was published on 1997-04-04 and is currently open access. It has received 275 citations till now. The article focuses on the topics: Nuclear receptor coactivator 2 & Nuclear receptor co-repressor 1.read more
Citations
More filters
Journal ArticleDOI
How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.
TL;DR: This review considers recent findings regarding GC action and generates criteria for determining whether a particular GC action permits, stimulates, or suppresses an ongoing stress-response or, as an additional category, is preparative for a subsequent stressor.
Journal ArticleDOI
Neuroendocrine Regulation of Immunity
TL;DR: This review focuses on the regulation of the immune response via the neuroendocrine system and the effects of interruptions of this regulatory loop at multiple levels in predisposition and expression of immune diseases and on mechanisms of glucocorticoid effects on immune cells and molecules.
Journal ArticleDOI
The Interplay between the Glucocorticoid Receptor and Nuclear Factor-κB or Activator Protein-1: Molecular Mechanisms for Gene Repression
TL;DR: The cellular signaling pathways identified as important regulators of inflammation are the signal transduction cascades mediated by the nuclear factor-kappaB and the activator protein-1, which can both be modulated by glucocorticoids.
Journal ArticleDOI
The biology of the glucocorticoid receptor: New signaling mechanisms in health and disease
TL;DR: In this article, the authors discuss the origin and molecular properties of the glucocorticoid receptor (GR) isoforms and their contribution to the specificity and sensitivity of glucoc corticoid signaling in healthy and diseased tissues.
Journal ArticleDOI
Genomic and nongenomic effects of glucocorticoids.
Cindy Stahn,Frank Buttgereit +1 more
TL;DR: Improved understanding of mechanisms of glucocorticoid action could enable the development of novel drugs with which to treat patients with inflammatory and autoimmune disease.
References
More filters
Journal ArticleDOI
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.
TL;DR: A method has been devised for the electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets that results in quantitative transfer of ribosomal proteins from gels containing urea.
Journal ArticleDOI
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.
TL;DR: In this article, the rat pancreas RNA was used as a source for the purification of alpha-amylase messenger ribonucleic acid (RBA) using 2-mercaptoethanol.
Journal ArticleDOI
Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane.
Journal ArticleDOI
The steroid and thyroid hormone receptor superfamily
TL;DR: A superfamily of regulatory proteins that include receptors for thyroid hormone and the vertebrate morphogen retinoic acid is identified, suggesting mechanisms underlying morphogenesis and homeostasis may be more ubiquitous than previously expected.
Journal ArticleDOI
The nuclear receptor superfamily: the second decade.
David J. Mangelsdorf,Carl S. Thummel,Miguel Beato,Peter Herrlich,Günther Schütz,Kazuhiko Umesono,Bruce Blumberg,Philippe Kastner,Manuel Mark,Pierre Chambon,Ronald M. Evans +10 more
TL;DR: This research presents a new probabilistic procedure called ‘spot-spot analysis’ to characterize the response of the immune system to the presence of E.coli.