Amanda L. Christie

TL;DR: Notch-dependent regulation of target genes in vivo in a patient-derived xenograft model of NOTCH1-mutant MCL is validated and enriched for regulators of B cell receptor (BCR) signaling, including the Src family kinase genes FYN, LYN, and BLK, and the signaling complex adaptor BLNK, as well as regulators of CD40 and cytokine signaling.

TL;DR: The data suggest that GNB1 mutations can promote tumorigenesis in more than one cell lineage, as observed in patients and in vivo treatment of the myeloid neoplasm with the dual PI3K/mTOR inhibitor BEZ235 suppressed GNB 1-induced signaling and markedly increased survival.

TL;DR: Two patient-derived xenografts (PDXs) in NSG mice from patients with DHL who relapsed after or were refractory to R-CHOP were generated and immunologic approaches that target DHLs may help overcome their resistance to cytotoxic chemotherapy were reasoned.

TL;DR: The Public Repository of Xenografts (PRoXe), an established repository of PDX models of leukemia and lymphoma, is established and extensively annotated with patient-level information, including demographics, phase of treatment, prior therapies, tumor immunophenotye, cytogenetics, and molecular diagnostics.

TL;DR: In this article, a dynamic BH3 profiling (DPB) is used to measure mitochondrial priming, or how close a cell is to its apoptotic threshold, which can identify which anti-apoptotic proteins (i.e. BCL2, BCL-XL, MCL-1) the cell relies on for survival.