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Alexandra N. Christodoulou
Researcher at Harvard University
Publications - 14
Citations - 723
Alexandra N. Christodoulou is an academic researcher from Harvard University. The author has contributed to research in topics: B cell & Leukemia. The author has an hindex of 8, co-authored 13 publications receiving 571 citations.
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Journal ArticleDOI
The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice
Elizabeth C. Townsend,Mark A. Murakami,Alexandra N. Christodoulou,Amanda L. Christie,Johannes Köster,Tiffany DeSouza,Elizabeth A. Morgan,Scott P. Kallgren,Huiyun Liu,Shuo-Chieh Wu,Olivia Plana,Joan Montero,Kristen E. Stevenson,Prakash Rao,Raga Vadhi,Michael Andreeff,Philippe Armand,Karen K. Ballen,Patrizia Barzaghi-Rinaudo,Sarah Cahill,Rachael A. Clark,Vesselina G. Cooke,Matthew S. Davids,Daniel J. DeAngelo,David M. Dorfman,Hilary Eaton,Benjamin L. Ebert,Julia Etchin,Brant Firestone,David C. Fisher,Arnold S. Freedman,Ilene Galinsky,Hui Gao,Jacqueline S. Garcia,Francine Garnache-Ottou,Timothy A. Graubert,Alejandro Gutierrez,Alejandro Gutierrez,Ensar Halilovic,Marian H. Harris,Zachary T. Herbert,Steven M. Horwitz,Giorgio Inghirami,Andrew M. Intlekofer,Moriko Ito,Shai Izraeli,Eric D. Jacobsen,Caron A. Jacobson,Sébastien Jeay,Irmela Jeremias,Michelle A. Kelliher,Raphael Koch,Marina Konopleva,Nadja Kopp,Steven M. Kornblau,Andrew L. Kung,Thomas S. Kupper,Nicole R. LeBoeuf,Ann S. LaCasce,Emma Lees,Loretta S. Li,A. Thomas Look,Masato Murakami,Markus Müschen,Donna Neuberg,Samuel Y. Ng,Oreofe O. Odejide,Stuart H. Orkin,Rachel R. Paquette,Andrew E. Place,Justine E. Roderick,Jeremy Ryan,Stephen E. Sallan,Brent Shoji,Lewis B. Silverman,Robert J. Soiffer,David P. Steensma,Kimberly Stegmaier,Richard Stone,Jerome Tamburini,Aaron R. Thorner,Paul Van Hummelen,Martha Wadleigh,Marion Wiesmann,Andrew P. Weng,Jens Wuerthner,David A. Williams,Bruce M. Wollison,Andrew A. Lane,Anthony Letai,Monica M. Bertagnolli,Jerome Ritz,Myles Brown,Henry W. Long,Jon C. Aster,Margaret A. Shipp,James D. Griffin,David M. Weinstock,David M. Weinstock +98 more
TL;DR: It is demonstrated that large studies of acute leukemia PDXs that mimic human randomized clinical trials can characterize drug efficacy and generate transcriptional, functional, and proteomic biomarkers in both treatment-naive and relapsed/refractory disease.
Journal ArticleDOI
Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia.
Shuo-Chieh Wu,Loretta S. Li,Nadja Kopp,Joan Montero,Bjoern Chapuy,Akinori Yoda,Amanda L. Christie,Huiyun Liu,Alexandra N. Christodoulou,Diederik van Bodegom,Jordy C.G. Van Der Zwet,Jacob V. Layer,Trevor Tivey,Andrew A. Lane,Jeremy Ryan,Samuel Y. Ng,Daniel J. DeAngelo,Richard Stone,David P. Steensma,Martha Wadleigh,Marian H. Harris,Emeline Mandon,Nicolas Ebel,Rita Andraos,Vincent Romanet,Arno Dölemeyer,Dario Sterker,Michael Zender,Scott J. Rodig,Masato Murakami,Francesco Hofmann,Frank C. Kuo,Michael J. Eck,Lewis B. Silverman,Stephen E. Sallan,Anthony Letai,Fabienne Baffert,Eric Vangrevelinghe,Thomas Radimerski,Christoph Gaul,David M. Weinstock,David M. Weinstock +41 more
TL;DR: CHZ868 potently suppressed the growth of CRLF2-rearranged human B-all cells, abrogated JAK2 signaling, and improved survival in mice with human or murine B-ALL, and these data support the testing of type II Jak2 inhibition in patients with JAK1-dependent leukemias and other disorders.
Journal ArticleDOI
Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia
Pierre Sujobert,Laury Poulain,Etienne Paubelle,Florence Zylbersztejn,Adrien Grenier,Mireille Lambert,Elizabeth C. Townsend,Jean-Marie Brusq,Edwige Nicodeme,Justine Decrooqc,Ina Nepstad,Alexa S. Green,Johanna Mondesir,Nathalie Jacque,Alexandra N. Christodoulou,Tiffany DeSouza,Olivier Hermine,Marc Foretz,Benoit Viollet,Catherine Lacombe,Patrick Mayeux,David M. Weinstock,Ivan C. Moura,Didier Bouscary,Jerome Tamburini +24 more
TL;DR: It is reported that the specific AMPK agonist GSK621 selectively kills acute myeloid leukemia (AML) cells but spares normal hematopoietic progenitors, which results from a unique synthetic lethal interaction involving concurrent activation of AMPK and mTORC1.
Journal ArticleDOI
Inhibition of USP10 induces degradation of oncogenic FLT3
Ellen Weisberg,Nathan J. Schauer,Jing Yang,Ilaria Lamberto,Laura M. Doherty,Shruti Bhatt,Atsushi Nonami,Chengcheng Meng,Anthony Letai,Renee Wright,Hong L. Tiv,Prafulla C. Gokhale,Maria Stella Ritorto,Virginia De Cesare,Matthias Trost,Alexandra N. Christodoulou,Amanda L. Christie,David M. Weinstock,Sophia Adamia,Richard Stone,Dharminder Chauhan,Kenneth C. Anderson,Hyuk-Soo Seo,Sirano Dhe-Paganon,Martin Sattler,Nathanael S. Gray,James D. Griffin,Sara J. Buhrlage +27 more
TL;DR: Targeting of USP10 showed efficacy in preclinical models of mutant- FLT3 AML, including cell lines, primary patient specimens and mouse models of oncogenic-FLT3-driven leukemia.
Journal ArticleDOI
Erratum: The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice (Cancer Cell (2016) 29 (574–586))
Elizabeth C. Townsend,Mark A. Murakami,Alexandra N. Christodoulou,Amanda L. Christie,Johannes Köster,Tiffany DeSouza,Elizabeth A. Morgan,Scott P. Kallgren,Huiyun Liu,Shuo-Chieh Wu,Olivia Plana,Joan Montero,Kristen E. Stevenson,Prakash Rao,Raga Vadhi,Michael Andreeff,Philippe Armand,Karen K. Ballen,Patrizia Barzaghi-Rinaudo,Sarah Cahill,Rachael A. Clark,Vesselina G. Cooke,Matthew S. Davids,Daniel J. DeAngelo,David M. Dorfman,Hilary Eaton,Benjamin L. Ebert,Julia Etchin,Brant Firestone,David C. Fisher,Arnold S. Freedman,Ilene Galinsky,Hui Gao,Jacqueline S. Garcia,Francine Garnache-Ottou,Timothy A. Graubert,Alejandro Gutierrez,Ensar Halilovic,Marian H. Harris,Zachary T. Herbert,Steven M. Horwitz,Giorgio Inghirami,Andrew M. Intlekofer,Moriko Ito,Shai Izraeli,Eric D. Jacobsen,Caron A. Jacobson,Sébastien Jeay,Irmela Jeremias,Michelle A. Kelliher,Raphael Koch,Marina Konopleva,Nadja Kopp,Steven M. Kornblau,Andrew L. Kung,Thomas S. Kupper,Nicole R. LeBoeuf,Ann S. LaCasce,Emma Lees,Loretta S. Li,A. Thomas Look,Masato Murakami,Markus Müschen,Donna Neuberg,Samuel Y. Ng,Oreofe O. Odejide,Stuart H. Orkin,Rachel R. Paquette,Andrew E. Place,Justine E. Roderick,Jeremy Ryan,Stephen E. Sallan,Brent Shoji,Lewis B. Silverman,Robert J. Soiffer,David P. Steensma,Kimberly Stegmaier,Richard Stone,Jerome Tamburini,Aaron R. Thorner,Paul Van Hummelen,Martha Wadleigh,Marion Wiesmann,Andrew P. Weng,Jens Wuerthner,David R. Williams,Bruce M. Wollison,Andrew A. Lane,Anthony Letai,Monica M. Bertagnolli,Jerome Ritz,Myles Brown,Henry W. Long,Jon C. Aster,Margaret A. Shipp,James D. Griffin,David M. Weinstock +96 more
TL;DR: Elizabeth C. Townsend, Mark A. Murakami, Alexandra Christodoulou, Amanda L. DeSouza, Elizabeth A. Morgan, Scott P. Stevenson, Prakash Rao, Raga Vadhi, Michael Andreeff, Philippe Armand, Karen K. Ballen, Patrizia Barzaghi-Rinaudo, Sarah Cahill, Rachael A. Clark, Vesselina G. Cooke, Matthew S. Clarke, and David M.