Cameron Fraser

TL;DR: It is demonstrated that the ibrutinib therapy favours selection and expansion of rare subclones already present before ibrUTinib treatment, and insight is provided into the heterogeneity of genetic changes associated with ibrutsinib resistance.

TL;DR: Using BH3 profiling, it is found that mitochondria of many adult somatic tissues, including brain, heart, and kidneys, are profoundly refractory to pro-apoptotic signaling, leading to cellular resistance to cytotoxic chemotherapies and ionizing radiation.

TL;DR: It is demonstrated that concurrent MEK + MCL1 inhibition induces apoptosis and tumor regression in KRAS-mutant non-small cell lung cancer (NSCLC) models, which respond poorly to MEK inhibition alone.

TL;DR: In this article, the authors found that mRNA and protein expression of angiotensin-converting enzyme 2 (ACE2), the cell entry receptor for the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), increases with advancing age in distal lung epithelial cells.

TL;DR: It is shown that antibody resistance within the bone marrow (BM) is not present upon early engraftment but develops during lymphoma progression, and a novel mechanism through which high-dose alkylating agents promote macrophage-dependent lymphoma clearance is defined.