A
Amanda Wheatley
Researcher at University of Nottingham
Publications - 25
Citations - 2416
Amanda Wheatley is an academic researcher from University of Nottingham. The author has contributed to research in topics: Gene & Population. The author has an hindex of 16, co-authored 25 publications receiving 2362 citations. Previous affiliations of Amanda Wheatley include Queen's University & Princess Anne Hospital.
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Journal ArticleDOI
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.
Daniel F. Gudbjartsson,Unnur S. Bjornsdottir,Unnur S. Bjornsdottir,Eva Halapi,Anna Helgadottir,Patrick Sulem,Gudrun M. Jonsdottir,Gudmar Thorleifsson,Hafdis T. Helgadottir,Valgerdur Steinthorsdottir,Hreinn Stefansson,Carolyn Williams,Jennie Hui,John Beilby,Nicole M. Warrington,Alan L. James,Alan L. James,Lyle J. Palmer,Gerard H. Koppelman,Andrea Heinzmann,Marcus Krueger,H. Marike Boezen,Amanda Wheatley,Janine Altmüller,Hyoung Doo Shin,Soo-Taek Uh,Hyun Sub Cheong,Brynja Jonsdottir,David Gislason,Choon-Sik Park,Linda M. Rasmussen,Celeste Porsbjerg,Jakob Werner Hansen,Vibeke Backer,Thomas Werge,Christer Janson,Ulla-Britt Jönsson,Maggie C.Y. Ng,Juliana C.N. Chan,Wing-Yee So,Ronald C.W. Ma,Svati H. Shah,Christopher B. Granger,Arshed A. Quyyumi,Allan I. Levey,Viola Vaccarino,Muredach P. Reilly,Daniel J. Rader,Michael J.A. Williams,Andre M. van Rij,Gregory T. Jones,Elisabetta Trabetti,Giovanni Malerba,Pier Franco Pignatti,Attilio Boner,Lydia Pescollderungg,Domenico Girelli,Oliviero Olivieri,Nicola Martinelli,Bjorn R. Ludviksson,Dora Ludviksdottir,Gudmundur I. Eyjolfsson,David O. Arnar,Gudmundur Thorgeirsson,Klaus A. Deichmann,Philip J. Thompson,Matthias Wjst,Ian P. Hall,Dirkje S. Postma,Thorarinn Gislason,Jeffrey R. Gulcher,Augustine Kong,Ingileif Jonsdottir,Ingileif Jonsdottir,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson +77 more
TL;DR: A genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly with myocardial infarction in six different populations.
Journal ArticleDOI
Association of Glu 27 β2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects
TL;DR: The study of beta 2-adrenoceptor genotype for the Gln/Glu 27 polymorphism and airway reactivity in 65 patients with mild to moderate asthma suggests that the genotype is important in the establishment of the asthmatic phenotype.
Journal ArticleDOI
The glutamine 27 β2-adrenoceptor polymorphism is associated with elevated IgE levels in asthmatic families
Jane Dewar,J Wilkinson,Amanda Wheatley,N. S. Thomas,Iolo Doull,Morton N,Pietro Liò,Harvey Jf,Liggett Sb,Holgate St,Ian P. Hall +10 more
TL;DR: It seems that although both amino acid 16 and 27 beta2-adrenoceptor polymorphisms are disease-modifying in subjects with asthma, they do not contribute markedly to the development of the asthmatic phenotype.
Journal ArticleDOI
β2-Adrenoceptor Polymorphism Determines Vascular Reactivity in Humans
John R. Cockcroft,Anastasios Gazis,Debbie J. Cross,Amanda Wheatley,Jane Dewar,Ian P. Hall,Joseph P. Noon +6 more
TL;DR: The &bgr;2-adrenoceptor genotype determines vascular responses to isoproterenol in forearm resistance vessels and in capacitance vessels.
Journal ArticleDOI
Beta2-adrenoceptor polymorphisms are in linkage disequilibrium, but are not associated with asthma in an adult population.
TL;DR: To determine the association between the β2‐adrenoceptor polymorphisms at amino acids 16 and 27 and markers of allergic disease and asthma per se in a random adult population, and to determine the degree of linkage disequilibrium existing between polymorphisms, nucleic acid residue 523 is studied.