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Amber E. de Groot
Researcher at Johns Hopkins University
Publications - 11
Citations - 1097
Amber E. de Groot is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Tumor microenvironment & Cancer. The author has an hindex of 6, co-authored 8 publications receiving 643 citations. Previous affiliations of Amber E. de Groot include University of California, Berkeley & Howard Hughes Medical Institute.
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Journal ArticleDOI
Targeting the tumour stroma to improve cancer therapy
TL;DR: An overview of the advances in understanding the complex cancer cell–tumour stroma interactions is provided and how this knowledge can result in more effective therapeutic strategies, which might ultimately improve patient outcomes are discussed.
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Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses
Jesse M. Jaynes,Rushikesh Sable,Michael Ronzetti,Wendy Bautista,Zachary Knotts,Abisola Abisoye-Ogunniyan,Dandan Li,Raul Calvo,Myagmarjav Dashnyam,Anju Singh,Theresa Guerin,Jason White,Sarangan Ravichandran,Parimal Kumar,Keyur Talsania,Vicky Chen,Anghesom Ghebremedhin,Balasubramanyam Karanam,Ahmad Bin Salam,Ruksana Amin,Taivan Odzorig,Taylor Aiken,Victoria Nguyen,Yansong Bian,Jelani C. Zarif,Amber E. de Groot,Monika Mehta,Lixin Fan,Xin Hu,Anton Simeonov,Nathan Pate,Mones Abu-Asab,Marc Ferrer,Noel Southall,Chan Young Ock,Yongmei Zhao,Henry Lopez,Serguei Kozlov,Natalia de Val,Natalia de Val,Clayton Yates,Bolormaa Baljinnyam,Juan J. Marugan,Udo Rudloff +43 more
TL;DR: RP-182 as mentioned in this paper is a synthetic 10-mer amphipathic analog of host defense peptides that selectively induces a conformational switch of the mannose receptor CD206 expressed on TAMs displaying an M2-like phenotype.
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Revisiting Seed and Soil: Examining the Primary Tumor and Cancer Cell Foraging in Metastasis
TL;DR: This review focuses on the selective pressures of the primary tumor "soil" that generate lethal metastatic "seeds" which is essential to understanding how and why metastasis occurs in prostate cancer.
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Epigenetic control of macrophage polarization: implications for targeting tumor-associated macrophages.
TL;DR: This review highlights the field’s current knowledge of key epigenetic enzymes and their pharmacologic modulators known to influence macrophage polarization and proposes a means for selectively targeting M2s thereby eliminating tumor-supporting TAMs while sparing tumor-inhibiting M1 TAMs.
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Live-Cell Labeling of Specific Protein Glycoforms by Proximity-Enhanced Bioorthogonal Ligation
Peter V. Robinson,Gabriela de Almeida-Escobedo,Amber E. de Groot,Julia L. McKechnie,Carolyn R. Bertozzi +4 more
TL;DR: It is shown that aptamer conjugates are amenable to detecting protein sialoforms by mass spectrometry, Western blotting, and flow cytometry, and it is expected this technology will be a useful platform for investigating the roles of protein-specific glycosylation in various cellular contexts.