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Amit Mogha
Researcher at Washington University in St. Louis
Publications - 18
Citations - 1404
Amit Mogha is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Myelin & Axon. The author has an hindex of 15, co-authored 18 publications receiving 1116 citations. Previous affiliations of Amit Mogha include City University of New York & College of Staten Island.
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Journal ArticleDOI
A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133.
Ines Liebscher,Ines Liebscher,Julia Schön,Sarah C. Petersen,Liane Fischer,Nina Auerbach,Lilian M. Demberg,Amit Mogha,Maxi Cöster,Kay Uwe Simon,Sven Rothemund,Kelly R. Monk,Torsten Schöneberg +12 more
TL;DR: It is shown that a short peptide sequence within the ectodomain of two aGPCRs functions as a tethered agonist and may prompt the development of specific ligands for this currently untargeted GPCR family.
Journal ArticleDOI
The Adhesion GPCR GPR126 Has Distinct, Domain-Dependent Functions in Schwann Cell Development Mediated by Interaction with Laminin-211
Sarah C. Petersen,Rong Luo,Ines Liebscher,Stefanie Giera,Sung Jin Jeong,Amit Mogha,Monica Ghidinelli,M. Laura Feltri,Torsten Schöneberg,Xianhua Piao,Kelly R. Monk +10 more
TL;DR: GPR126 has domain-specific functions in SC development whereby the NTF is necessary and sufficient for axon sorting, whereas the CTF promotes wrapping through cAMP elevation, and this work suggests a model in which Laminin-211 mediates GPR126-induced cAMP levels to control early and late stages of SC development.
Journal ArticleDOI
The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6
Alexander Küffer,Asvin K. K. Lakkaraju,Amit Mogha,Sarah C. Petersen,Kristina Airich,Cédric Doucerain,Rajlakshmi Marpakwar,Pamela Bakirci,Assunta Senatore,Arnaud Monnard,Carmen Schiavi,Mario Nuvolone,Bianka L. Grosshans,Simone Hornemann,Frederic Bassilana,Kelly R. Monk,Adriano Aguzzi +16 more
TL;DR: It is shown that the cAMP concentration in sciatic nerves from PrPC-deficient mice is reduced, suggesting that PrPC acts via a G protein-coupled receptor (GPCR) and promotes myelin homeostasis through flexible tail-mediated Gpr126 agonism.
Journal ArticleDOI
Gpr126 functions in Schwann cells to control differentiation and myelination via G-protein activation.
Amit Mogha,Andrew E. Benesh,Chinmoy Patra,Felix B. Engel,Felix B. Engel,Torsten Schöneberg,Ines Liebscher,Kelly R. Monk +7 more
TL;DR: A model in which Gpr126 functions in SCs for proper development and myelination is supported and evidence that these functions are mediated via G-protein-signaling pathways is provided.
Journal ArticleDOI
The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development
Stefanie Giera,Yiyu Deng,Rong Luo,Sarah D. Ackerman,Amit Mogha,Kelly R. Monk,Yanqin Ying,Sung Jin Jeong,Manabu Makinodan,Allison R. Bialas,Bernard S. Chang,Beth Stevens,Gabriel Corfas,Xianhua Piao +13 more
TL;DR: It is demonstrated that loss of Gpr56 leads to hypomyelination of the central nervous system in mice, and GPR56 is defined as a cell-autonomous regulator of oligodendrocyte development.