Amr Abouelleil

TL;DR: A high-quality draft genome sequence of the domestic dog is reported, together with a dense map of single nucleotide polymorphisms (SNPs) across breeds, to shed light on the structure and evolution of genomes and genes.

TL;DR: The striking difference in diversity between the German and French outbreak samples is consistent with several hypotheses, including a bottleneck that purged diversity in the German isolates, variation in mutation rates in the two E. coli outbreak populations, or uneven distribution of Diversity in the seed populations that led to each outbreak.

TL;DR: By applying a new laboratory design and new assembly algorithm to 16 samples, it is demonstrated that assemblies exceeding finished quality can be obtained from whole-genome shotgun data and automated computation.

TL;DR: An improved genome build, canFam3.1, is presented and a much-improved annotation of the canine genome is provided and regulatory functions for several of the novel non-coding transcripts are suggested.

TL;DR: The analysis favors the H2 configuration and sequence haplotype as the likely great ape and human ancestral state, with inversion recurrences during primate evolution, perhaps explaining its tendency to undergo microdeletion associated with mental retardation in European populations.