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April Cook
Researcher at Harvard University
Publications - 30
Citations - 4881
April Cook is an academic researcher from Harvard University. The author has contributed to research in topics: Mesopelagic zone & Genome. The author has an hindex of 15, co-authored 29 publications receiving 4454 citations. Previous affiliations of April Cook include Massachusetts Institute of Technology & UPRRP College of Natural Sciences.
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Journal ArticleDOI
Genome sequence, comparative analysis and haplotype structure of the domestic dog
Kerstin Lindblad-Toh,Claire M. Wade,Claire M. Wade,Tarjei S. Mikkelsen,Tarjei S. Mikkelsen,Elinor K. Karlsson,Elinor K. Karlsson,David B. Jaffe,Michael Kamal,Michele Clamp,Jean L. Chang,Edward J. Kulbokas,Michael C. Zody,Evan Mauceli,Xiaohui Xie,Matthew Breen,Robert K. Wayne,Elaine A. Ostrander,Chris P. Ponting,Francis Galibert,Douglas Smith,Pieter J. deJong,Ewen F. Kirkness,Pablo Alvarez,Tara Biagi,William Brockman,Jonathan Butler,Chee-Wye Chin,April Cook,James Cuff,Mark J. Daly,Mark J. Daly,David DeCaprio,Sante Gnerre,Manfred Grabherr,Manolis Kellis,Michael Kleber,Carolyne Bardeleben,Leo Goodstadt,Andreas Heger,Christophe Hitte,Lisa Kim,Klaus-Peter Koepfli,Heidi G. Parker,John P. Pollinger,Stephen M. J. Searle,Nathan B. Sutter,Rachael Thomas,Caleb Webber,Jennifer Baldwin,Jennifer Baldwin,Adal Abebe,Amr Abouelleil,Lynne Aftuck,Mostafa Ait-zahra,Tyler Aldredge,Nicole R. Allen,Peter An,Scott Anderson,Claudel Antoine,Harindra Arachchi,Ali Aslam,Laura Ayotte,Pasang Bachantsang,Andrew Barry,Tashi Bayul,Mostafa Benamara,Aaron M. Berlin,Daniel Bessette,Berta Blitshteyn,Toby Bloom,Jason Blye,Leonid Boguslavskiy,Claude Bonnet,Boris Boukhgalter,Adam Brown,Patrick Cahill,Nadia Calixte,Jody Camarata,Yama Cheshatsang,Jeffrey Chu,Mieke Citroen,Alville Collymore,Patrick Cooke,Tenzin Dawoe,Riza M. Daza,Karin Decktor,Stuart DeGray,Norbu Dhargay,Kimberly Dooley,Kathleen Dooley,Passang Dorje,Kunsang Dorjee,Lester Dorris,Noah Duffey,Alan Dupes,Osebhajajeme Egbiremolen,Richard Elong,Jill Falk,Abderrahim Farina,Susan Faro,Diallo Ferguson,Patricia Ferreira,Sheila A. Fisher,Michael Fitzgerald,Karen Foley,Chelsea D. Foley,Alicia Franke,Dennis C. Friedrich,Diane Gage,Manuel Garber,Gary Gearin,Georgia Giannoukos,Tina Goode,Audra Goyette,Joseph Graham,Edward Grandbois,Kunsang Gyaltsen,Nabil Hafez,Daniel S. Hagopian,Birhane Hagos,Jennifer Ruth Sadler Hall,Claire M. Healy,Ryan Hegarty,Tracey Honan,Andrea Horn,Nathan Houde,Leanne Hughes,Leigh Anne Hunnicutt,M. Husby,Benjamin Jester,Charlien Jones,Asha Kamat,Ben Kanga,Cristyn Kells,Dmitry Khazanovich,Alix Chinh Kieu,Peter Kisner,Mayank Kumar,Krista Lance,Thomas E. Landers,Marcia Lara,William H. Lee,Jean-Pierre Leger,Niall J. Lennon,Lisa Leuper,Sarah LeVine,Jinlei Liu,Xiaohong Liu,Yeshi Lokyitsang,Tashi Lokyitsang,Annie Lui,Jan Macdonald,John E. Major,Richard Marabella,Kebede Maru,Charles Matthews,Susan McDonough,Teena Mehta,James Meldrim,Alexandre Melnikov,Louis Meneus,Atanas Mihalev,Tanya Mihova,Karen Hughes Miller,Rachel Mittelman,Valentine Mlenga,Leonidas Mulrain,Glen Munson,Adam Navidi,Jerome Naylor,Tuyen T. Nguyen,Nga Nguyen,Cindy Nguyen,Thu Nguyen,Robert Nicol,Nyima Norbu,Choe Norbu,Nathaniel Novod,Tenchoe Nyima,Peter Olandt,Barry O'Neill,Keith O'Neill,Sahal Osman,Lucien Oyono,Christopher Patti,Danielle Perrin,Pema Phunkhang,Fritz Pierre,Margaret Priest,Anthony Rachupka,Sujaa Raghuraman,Rayale Rameau,Verneda Ray,Christina Raymond,Filip Rege,Cecil Rise,Julie Rogers,Peter Rogov,Julie Sahalie,Sampath Settipalli,Ted Sharpe,Terrance Shea,Mechele Sheehan,Ngawang Sherpa,Jianying Shi,Diana M. Shih,Jessie Sloan,Cherylyn Smith,Todd Sparrow,John Stalker,Nicole Stange-Thomann,Sharon Stavropoulos,Catherine Stone,Sabrina M. Stone,Sean M. Sykes,Pierre Tchuinga,Pema Tenzing,Senait Tesfaye,Dawa Thoulutsang,Yama Thoulutsang,Kerri Topham,Ira Topping,Tsamla Tsamla,Helen Vassiliev,Vijay Venkataraman,Andy Vo,Tsering Wangchuk,Tsering Wangdi,Michael Weiand,Jane E. Wilkinson,Adam Wilson,Shailendra Yadav,Shuli Yang,Xiaoping Yang,Geneva Young,Qing Yu,Joanne Zainoun,Lisa Zembek,Andrew Zimmer,Eric S. Lander,Eric S. Lander +241 more
TL;DR: A high-quality draft genome sequence of the domestic dog is reported, together with a dense map of single nucleotide polymorphisms (SNPs) across breeds, to shed light on the structure and evolution of genomes and genes.
Journal ArticleDOI
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
Tarjei S. Mikkelsen,Tarjei S. Mikkelsen,Matthew Wakefield,Bronwen Aken,Chris T. Amemiya,Jean L. Chang,Shannon E. Duke,Manuel Garber,Andrew J. Gentles,Andrew J. Gentles,Leo Goodstadt,Andreas Heger,Jerzy Jurka,Michael Kamal,Evan Mauceli,Stephen M. J. Searle,Ted Sharpe,Michelle L. Baker,Mark A. Batzer,Panayiotis V. Benos,Katherine Belov,Michele Clamp,April Cook,James Cuff,Radhika Das,Lance S. Davidow,Janine E. Deakin,Melissa Fazzari,Jacob L. Glass,Manfred Grabherr,John M. Greally,Wanjun Gu,Timothy A. Hore,Gavin A. Huttley,Michael Kleber,Randy L. Jirtle,Edda Koina,Jeannie T. Lee,Shaun Mahony,Marco A. Marra,Robert D. Miller,Robert D. Nicholls,Mayumi Oda,Anthony T. Papenfuss,Zuly E. Parra,David D. Pollock,David A. Ray,Jacqueline E. Schein,Terence P. Speed,Katherine Thompson,John L. VandeBerg,Claire M. Wade,Claire M. Wade,Jerilyn A. Walker,Paul D. Waters,Caleb Webber,Jennifer R. Weidman,Xiaohui Xie,Michael C. Zody,Jennifer Baldwin,Amr Abdouelleil,Jamal Abdulkadir,Adal Abebe,Brikti Abera,Justin Abreu,St Christophe Acer,Lynne Aftuck,Allen Alexander,Peter An,Erica Anderson,Scott Anderson,Harindra Arachi,Marc Azer,Pasang Bachantsang,Andrew Barry,Tashi Bayul,Aaron M. Berlin,Daniel Bessette,Toby Bloom,Jason Blye,Leonid Boguslavskiy,Claude Bonnet,Boris Boukhgalter,Imane Bourzgui,Adam Brown,Patrick Cahill,Sheridon Channer,Yama Cheshatsang,Lisa Chuda,Mieke Citroen,Alville Collymore,Patrick Cooke,Maura Costello,Katie D'Aco,Riza M. Daza,Georgius De Haan,Stuart DeGray,Christina Demaso,Norbu Dhargay,Kimberly Dooley,Erin E. Dooley,Missole Doricent,Passang Dorje,Kunsang Dorjee,Alan Dupes,Richard Elong,Jill Falk,Abderrahim Farina,Susan Faro,Diallo Ferguson,Sheila Fisher,Chelsea D. Foley,Alicia Franke,Dennis C. Friedrich,Loryn Gadbois,Gary Gearin,Christina R. Gearin,Georgia Giannoukos,Tina Goode,Joseph Graham,Edward Grandbois,Sharleen Grewal,Kunsang Gyaltsen,Nabil Hafez,Birhane Hagos,Jennifer L. Hall,Charlotte Henson,Andrew Hollinger,Tracey Honan,Monika D. Huard,Leanne Hughes,Brian Hurhula,M. Erii Husby,Asha Kamat,Ben Kanga,Seva Kashin,Dmitry Khazanovich,Peter Kisner,Krista Lance,Marcia Lara,William Lee,Niall J. Lennon,Frances Letendre,Rosie Levine,Alex Lipovsky,Xiaohong Liu,Jinlei Liu,Shangtao Liu,Tashi Lokyitsang,Yeshi Lokyitsang,Rakela Lubonja,Annie Lui,Pen MacDonald,Vasilia Magnisalis,Kebede Maru,Charles Matthews,William McCusker,Susan McDonough,Teena Mehta,James Meldrim,Louis Meneus,Oana Mihai,Atanas Mihalev,Tanya Mihova,Rachel Mittelman,Valentine Mlenga,Anna Montmayeur,Leonidas Mulrain,Adam Navidi,Jerome Naylor,Tamrat Negash,Thu Nguyen,Nga Nguyen,Robert Nicol,Choe Norbu,Nyima Norbu,Nathaniel Novod,Barry O'Neill,Sahal Osman,Eva Markiewicz,Otero L. Oyono,Christopher Patti,Pema Phunkhang,Fritz Pierre,Margaret Priest,Sujaa Raghuraman,Filip Rege,Rebecca Reyes,Cecil Rise,Peter Rogov,Keenan Ross,Elizabeth P. Ryan,Sampath Settipalli,Terry Shea,Ngawang Sherpa,Lu Shi,Diana Shih,Todd Sparrow,Jessica Spaulding,John Stalker,Nicole Stange-Thomann,Sharon Stavropoulos,Catherine Stone,Christopher Strader,Senait Tesfaye,Talene Thomson,Yama Thoulutsang,Dawa Thoulutsang,Kerri Topham,Ira Topping,Tsamla Tsamla,Helen Vassiliev,Andy Vo,Tsering Wangchuk,Tsering Wangdi,Michael Weiand,Jane Wilkinson,Adam Wilson,Shailendra Yadav,Geneva Young,Qing Yu,Lisa Zembek,Danni Zhong,Andrew Zimmer,Zac Zwirko,David B. Jaffe,Pablo Alvarez,William Brockman,Jonathan Butler,Chee Whye Chin,Sante Gnerre,Iain MacCallum,Jennifer A. Marshall Graves,Chris P. Ponting,Matthew Breen,Paul B. Samollow,Eric S. Lander,Eric S. Lander,Kerstin Lindblad-Toh +238 more
TL;DR: A high-quality draft of the genome sequence of the grey, short-tailed opossum is reported, indicating a strong influence of biased gene conversion on nucleotide sequence composition, and a relationship between chromosomal characteristics and X chromosome inactivation.
Journal ArticleDOI
Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting
Andrew J. Aguirre,Robin M. Meyers,Barbara A. Weir,Francisca Vazquez,Cheng-Zhong Zhang,Uri Ben-David,April Cook,Gavin Ha,William F. Harrington,Mihir B. Doshi,Maria Kost-Alimova,Stanley Gill,Han Xu,Levi D. Ali,Guozhi Jiang,Sasha Pantel,Yenarae Lee,Amy Goodale,Andrew D. Cherniack,Coyin Oh,Gregory V. Kryukov,Glenn S. Cowley,Levi A. Garraway,Kimberly Stegmaier,Charles W. M. Roberts,Todd R. Golub,Matthew Meyerson,David E. Root,Aviad Tsherniak,William C. Hahn +29 more
TL;DR: It is found that the number of CRISPR/Cas9-induced DNA breaks dictates a gene-independent antiproliferative response in cells, which has practical implications for using CRISpr/cas9 to interrogate cancer gene function and illustrate that cancer cells are highly sensitive to site-specific DNA damage, which may provide a path to novel therapeutic strategies.
Journal ArticleDOI
An improved canine genome and a comprehensive catalogue of coding genes and non-coding transcripts.
Marc P. Hoeppner,Andrew L. Lundquist,Andrew L. Lundquist,Mono Pirun,Jennifer R. S. Meadows,Neda Zamani,Jeremy Johnson,Görel Sundström,April Cook,Michael Fitzgerald,Ross Swofford,Evan Mauceli,Behrooz Torabi Moghadam,Anna Greka,Jessica Alföldi,Amr Abouelleil,Lynne Aftuck,Daniel Bessette,Aaron M. Berlin,Adam Brown,Gary Gearin,Annie Lui,Pendexter Macdonald,Margaret Priest,Terrance Shea,Jason Turner-Maier,Andrew Zimmer,Eric S. Lander,Federica Di Palma,Federica Di Palma,Kerstin Lindblad-Toh,Kerstin Lindblad-Toh,Manfred Grabherr,Manfred Grabherr +33 more
TL;DR: An improved genome build, canFam3.1, is presented and a much-improved annotation of the canine genome is provided and regulatory functions for several of the novel non-coding transcripts are suggested.
Journal ArticleDOI
MNase titration reveals differences between nucleosome occupancy and chromatin accessibility
Jakub Mieczkowski,April Cook,Sarah K. Bowman,Britta Mueller,Burak H. Alver,Sharmistha Kundu,Aimee M. Deaton,Jennifer A. Urban,Erica Larschan,Peter J. Park,Robert E. Kingston,Michael Y. Tolstorukov +11 more
TL;DR: It is found that changes in accessibility at enhancers, promoters and other regulatory regions do not correlate with changes in nucleosome occupancy, which reveals novel principles of chromatin regulation.